Concept

Matrix metalloproteinase

Related publications (99)

3D niche microarrays for systems-level analyses of cell fate

Matthias Lütolf, Adrian Ranga, Samy Gobaa, Katarzyna Mosiewicz, Andrea Negro, Yuya Okawa

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...

Nature Publishing Group2014

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Manuel Andreas Fankhauser

Besides being a physical scaffold to maintain tissue morphology, the extracellular matrix (ECM) is actively involved in regulating cell and tissue function during development and organ homeostasis. It does so by acting via biochemical, biomechanical, and b ...

Journal Of Visualized Experiments2014

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Stéphanie Lacour, Alba Carla De Luca

Peripheral nerve injury is a serious problem affecting significantly patients' life. Autografts are the "gold standard" used to repair the injury gap, however, only 50% of patients fully recover from the trauma. Artificial conduits are a valid alternative ...

Shenyang Editorial Dept Neural Regeneration Res2014

Living-Engineered Valves for Transcatheter Venous Valve Repair

Peter Modregger, Marco Stampanoni

Background: Chronic venous insufficiency (CVI) represents a major global health problem with increasing prevalence and morbidity. CVI is due to an incompetence of the venous valves, which causes venous reflux and distal venous hypertension. Several studies ...

2014

Comparative behavior of relevant micropollutants in different water matrices by uv254 and simulated solar light irradiation and neutral photo-fenton process

César Pulgarin, Andrzej Sienkiewicz, Dominique Grandjean, Luiz Felippe De Alencastro

This is a comparative study of photolytic degradation under exposure to UV254 nm and solar-simulator irradiation of a mixture of eight equally concentrated relevant micropollutants (atenolol, benzotriazole, clarithromycin, gabapentin, methylbenzotriazole, ...

2014

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

Patrycja Nowak-Sliwinska

The endothelium plays a pivotal role in the progression of solid tumors and is considered a highly relevant target for therapy. However, it emerges that current clinical angiogenesis inhibitors that act through inhibition of tumor-derived growth factors ar ...

2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Matthias Lütolf, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Adrian Ranga

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013

Engineering the Regenerative Microenvironment with Biomaterials

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Federico Tortelli, Jeffrey James Rice

Modern synthetic biomaterials are being designed to integrate bioactive ligands within hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced biomaterials are only beginning to be used to simulate the complex spatio-tempor ...

Wiley-Blackwell2013

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Marco Pisano, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

Integration of mechanotransduction concepts in bone tissue engineering

Dominique Pioletti

Mechanical stimulus has been identified for a long time as a key player in the adaptation of the musculo-skeletal tissues to their function. Mechanical loading is then an intrinsic variable to be considered when new developments are proposed in bone tissue ...

Taylor & Francis2013

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