Concept
Matrix metalloproteinase
Related publications (99)
Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells
The behaviour of cells cultured within three-dimensional (3D) structures rather than onto two-dimensional (2D) culture plastic more closely reflects their in vivo responses. Consequently, 3D culture systems are becoming crucial scientific tools in cancer c ...
Elsevier2010Fluidic microstructuring of alginate hydrogels for the single cell niche
Jürgen Brugger, Philippe Renaud, Thomas Michael Braschler, Kristopher Pataky, Ana Valero, Ludovica Colella
Controlling alginate gel formation by diffusion of Ca2+ ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It offers the possibility of exposing cells under biocompatible co ...
Royal Society of Chemistry2010Myofibroblasts work best under stress
Boris Hinz, Pierre Jean Arnould Wipff
Myofibroblasts are reparative connective tissue cells that contribute to the reconstruction of injured tissue by secreting new extracellular matrix and by exerting high contractile force. Deregulation of these activities results in tissue contracture and d ...
Elsevier2009Cell-responsive hydrogel for encapsulation of vascular cells
The in vitro potential of a synthetic matrix metalloproteinase (MMP)-responsive poly(ethylene glycol) (PEG)-based hydrogel as a bioactive co-encapsulation system for vascular cells and a small bioactive peptide, thymosin beta 4 (T beta 4), was examined. We ...
2009Sequential build-up of hydrogel environments around single cells
Philippe Renaud, Thomas Michael Braschler, Ana Valero, Anja Kunze, Ludovica Colella, Joël Theytaz, Grazia Loche
Controlling alginate gel formation by diffusion of Ca ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It gives the possibility of exposing cells under biocompatible condi ...
2009Integration column: Artificial ECM: expanding the cell biology toolbox in 3D
Many crucial cellular processes in our tissues are governed by complex, spatio-temporally regulated interactions between cells and their extracellular matrix (ECM). These interactions can be studied using well-established 3D in vitro model systems such as ...
20093D multi-chamber fluidic systems for analysis of angiogenesis in biomaterials: development, characterization and applications
The cellular processes leading to capillary morphogenesis depend on external stimuli, in particular flow and morphogen gradients. Several devices have been designed to study these interactions in vitro. However, most of these devices allow a single experim ...
2009Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage
Jeffrey Alan Hubbell, Conlin O'Neil, Dominique André Rothenfluh
The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...
Nature Publishing Group2008Microfluidics-Generated Immobilized Biomolecule Gradients on Hydrogels
Extracellular matrix (ECM)-tethered morphogen gradients play an important role in tissue development and regeneration. There is currently a limited set of model systems that can mimic these gradients in an artificial ECM-like environment. Microfluidics off ...
2008Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship
Boris Hinz, Pierre Jean Arnould Wipff
Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit intracellular stress to their environment. We here review the more recently discovered role of integrins in activating the pleiotrophic cytokine transforming g ...
Elsevier2008