Oxygen therapy

Summary

Oxygen therapy, also referred to as supplemental oxygen, is the use of oxygen as medical treatment. Supplemental oxygen can also refer to the use of oxygen enriched air at altitude. Acute indications for therapy include hypoxemia (low blood oxygen levels), carbon monoxide toxicity and cluster headache. It may also be prophylactically given to maintain blood oxygen levels during the induction of anesthesia. Oxygen therapy is often useful in chronic hypoxemia caused by conditions such as severe COPD or cystic fibrosis. Oxygen can be delivered via nasal cannula, face mask, or endotracheal intubation at normal atmospheric pressure, or in a hyperbaric chamber. It can also be given through bypassing the airway, such as in ECMO therapy. Oxygen is required for normal cellular metabolism. However, excessively high concentrations can result in oxygen toxicity, leading to lung damage and respiratory failure. Higher oxygen concentrations

Official source

https://en.wikipedia.org/wiki/Oxygen_therapy

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N-removal optimization by various aeration strategies

Simon Taillard

In order to improve the purification capacity of an aerobic granular sludge, two aeration strategies were designed and tested. The goal was to optimize the nitrogen removal performances via various oxygen patterns in the aeration phase of the reactor cycle. The main process driving theses patterns is that a difference between oxygen concentrations in the reactor will modify the size of the anoxic inner zone of a granule. The first aeration was based on a succession of oxygen peaks (50%DO) and semi anoxic valleys (5%DO). The second was based on a short pulse of oxygen followed by the hermetical isolation of the reactor and a continuous recirculation of the pulse. The objective was to get an n-removal superior to 82%, results of a previous article, and if possible better than 88%, results of a previous experiment in the lab. The succession of oxygenated peaks strategy worked well and gave good results, as the n-removal was increasing with the sludge bed height and time. However, due to laboratories problem and to the shortness of the time-slots available to experiment, the system could not have the time to stabilize and no constant removal value could be found. Therefore, the average n-removal was equal to 69% for 40 days of experimentation, with some peak over 80%. The highest value observed was 88% of n-removal. The recirculation strategy gave unsatisfactory results, actually unexplained. The first recirculation led to the disappearance of high nitrification capacity, giving an n-removal percentage of 48%. The second attempt was worse, as the oxygen concentration started to behave incoherently and over-oxygenated the system. This behavior still lacks a proper explanation and only hypotheses can actually be proposed. Besides these mains results, the surveillance of the sludge in the reactors allowed the discovery of a bias in the evaluation of the suspended biomass measurement. It was explained by the fact that heavier granules tend not to mix well, and therefore the system could not be considered homogenous. The bias was created because measurements were made at different height between the two reactors. In order to remove it, a linear transformation was developed and tested. The first results seem to be consistent, but due to the lack of experimenting time, the working hypothesis could not be deepened. Another bias that was spotted is the possible influence of the operator during the aeration cycle measurement. Three of four off-trend points in the first experiment originated from a cycle measurement. The data set was too small to draw strong conclusions upon the bias. An extended survey of the cycle measurement and their supposed off-trend consequences in previous and future experiments could clarify the situation.

2009

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The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the pO(2) also enables to obtain interesting fundamental information regarding the metabolic activities in cells and tissues. The development of time-resolved luminescence measurement (TRLM) methods combined with the availability of new oxygen-sensitive molecular probes is at the origin of the significant progress that have been achieved during these past decades to measure the pO(2) in living organisms. These probes include porphyrins, such as aminolevulinic acid-induced protoporphyrin IX (PPIX), which is an approved photosensitizer. Using the photosensitizer to probe the pO(2) is of high interest in PDT since the level of oxygen is measured at the precise location where the phototoxic mechanisms take place. However, PPIX has drawbacks to measure the pO(2) by TRLM, including its significant photobleaching. Since the PPIX excitation during pO(2) measurements leads to the generation of its photoproducts, we studied the impact of their luminescence on the measurement of the PPIX triplet state lifetime in solution and in vivo on the Chick's Chorioallantoic Membrane (CAM) model. We performed this study under various oxygen conditions. Our results indicate that perturbations induced by these photoproducts can be avoided if the PPIX luminescence is detected between 620 and 640 nm, or if PPIX is excited at 405 nm with light doses < 1 J/cm(2).

Spie-Int Soc Optical Engineering2017

Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

Emmanuel Louis Arthur Gerelli, Veronika Huntosova, Georges Wagnières, Matthieu Zellweger

The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproducts in vitro and in vivo. The influence of their luminescence on the measured Protoporphyrin IX delayed fluorescence lifetimes was studied in solution and in vivo on the Chick's chorioallantoic membrane (CAM) model under various oxygen enriched air conditions (0mmHg, 37mmHg and 155mmHg). The presence of photoproducts disturbs such measurements since the delayed fluorescence emission of some of them spectrally overlaps with that of Protoporphyrin IX. One possible way to avoid this obstacle is to detect Protoporphyrin IX's delayed fluorescence lifetime in a very specific spectral range (620-640nm). Another possibility is to excite Protoporphyrin IX with light doses much lower than 10J/cm(2), quite possibly as low as a fraction 1J/cm(2) at 405nm. This leads to an increased accuracy of pO2 detection. Furthermore, this method allows combination of diagnosis and therapy in one step. This helps to improve detection systems and real-time identification of tissue respiration, which is tuned for the detection of PpIX luminescence and not its photoproducts.

Elsevier Science Sa2016

N-removal optimization by various aeration strategies

Simon Taillard

2009