Publications related to Single-nucleotide polymorphism

Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

Sandrine Madeleine Suzanne Georgeon, Oliver Hantschel, Sina Maren Reckel

We present a rapid and high-throughput yeast and flow cytometry based method for predicting kinase inhibitor resistance mutations and determining kinase peptide substrate specificity. Despite the widespread success of targeted kinase inhibitors as cancer t ...

AMER CHEMICAL SOC2019

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

Henning Paul-Julius Stahlberg, Ricardo Cesar Guerrero Ferreira, Pratibha Kumari

Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson’s disease (PD). Previously, we reported the structure of alpha-synuclein fibrils (residues 1–121), composed of two protofibrils that a ...

2019

HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected

Jacques Fellay, Christian Axel Wandall Thorball

Background: HIV's capacity to escape immune recognition by human leukocyte antigen (HLA) is a core component of HIV pathogenesis. A better understanding of the distribution of HLA class I in HIV-infected patients would improve our knowledge of pathogenesis ...

LIPPINCOTT WILLIAMS & WILKINS2019

Unified picture of lattice instabilities in metallic transition metal dichalcogenides

Oleg Yazyev, Diego José Pasquier

Transition metal dichalcogenides (TMDs) in the 1T polymorph are subject to a rich variety of periodic lattice distortions, often referred to as charge-density waves (CDWs) when not too strong. We study from first principles the fermiology and phonon disper ...

AMER PHYSICAL SOC2019

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Maya Roinishvili, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

Predicting polymorphism in molecular crystals using orientational entropy

Pablo Miguel Piaggi, Michele Parrinello

We introduce a computational method to discover polymorphs in molecular crystals at finite temperature. The method is based on reproducing the crystallization process starting from the liquid and letting the system discover the relevant polymorphs. This id ...

2018

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma

Jacques Fellay, Patrick Taffe

Background: Kaposi's sarcoma, the most common AIDS-related cancer, represents a major public concern in resource-limited countries. Single nucleotide polymorphisms within the Interferon lambda 3/4 region (IFNL3/4) determine the expression, function of IFNL ...

LIPPINCOTT WILLIAMS & WILKINS2018

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

Jeffrey David Jensen, Sebastian Matuszewski, Susanne Petra Pfeifer

Intrahost and interhost assessments of viral diversity are often treated as measures of separate and distinct evolutionary processes, with numerous investigations reporting seemingly incompatible results between the two. For example, in human cytomegalovir ...

Amer Soc Microbiology2017

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Single-nucleotide polymorphism

Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected

Unified picture of lattice instabilities in metallic transition metal dichalcogenides

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

Predicting polymorphism in molecular crystals using orientational entropy

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma

Detection and benchmarking of somatic mutations in cancer genomes using RNA-seq data

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

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Chat with Graph Search

Predicting polymorphism in molecular crystals using orientational entropy

HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma

Detection and benchmarking of somatic mutations in cancer genomes using RNA-seq data

On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

Unified picture of lattice instabilities in metallic transition metal dichalcogenides

Computational and Statistical analyses of Molecular Evolution and Demography using Large-scale Sequencing Data

Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype