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The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types. Defective myosin-IIA complexes are presumed to perturb megakaryocyte (MK) differentiati ...
Intrauterine Growth Restriction (IUGR) due to placental insufficiency affects 5-10% of all pregnancies and it is associated with a wide range of short and long-term neurodevelopmental disorders. Different approaches have been considered to understand IUGR ...
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are structurally related bioactive lipids with growth factor-like activities. LPA and SIP are naturally produced in vivo by blood platelets upon platelet aggregation and at least in vitro by fib ...
Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensit ...
Carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue ...
Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre rec ...
1999
Interleukin (IL)-12 synergizes with other cytokines to stimulate the proliferation and differentiation of early hematopoietic progenitors in vitro. However, in vivo administration of IL-12 decreases peripheral blood counts and bone marrow hematopoiesis. He ...
1995
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A novel polyol synthesis was adopted to synthesize nano-structured LiMnPO4. This route yields well-crystallized nanoparticles with platelet morphology that are only similar to 30 nm thick oriented in the b direction. The obtained material presented a good ...
The short-term mechanical strength of platelet-reinforced polymer composites was modeled using classical two-dimensional stress-transfer analysis. The stress field in the platelet and at the platelet/matrix interface was described in the presence of a matr ...
The short-term mechanical strength of platelet-reinforced polymer composites was modeled using classical two-dimensional stress-transfer analysis. The stress field in the platelet and at the platelet/matrix interface was described in the presence of a matr ...
