Concept

Neural stem cell

Related publications (296)

GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys

Human neural progenitor cells (hNPCs) have been proposed as a potential source of cells for ex vivo gene therapy. In this pilot study, three 5-year-old female cynomolgus monkeys received a single intracarotid infusion of MPTP, followed 1 week later by MRI- ...

2008

Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces

Wulfram Gerstner, Carl Petersen, Laurent Badel, Sandrine Lefort, Romain Brette

Neuronal response properties are typically probed by intracellular measurements of current-voltage (I-V) relationships during application of current or voltage steps. Here we demonstrate the measurement of a novel I-V curve measured while the neuron exhibi ...

American Physiological Society2008

Neural commitment of embryonic stem cells: molecules, pathways and potential for cell therapy

David Michael Suter

The study of neuronal differentiation of embryonic stem cells has raised major interest over recent years. It allows a better understanding of fundamental aspects of neurogenesis and, at the same time, the generation of neurons as tools for various applica ...

Wiley-Blackwell2008

What signals operate in the mammary niche?

Cathrin Brisken, Tamara Tanos

Adult stem cells reside in a specialized microenvironment, the niche, which controls their behavior. As mammary stem cells, and consequently their niches, are still poorly defined, we look at better-characterized adult mammalian stem cell niches in the hem ...

2008

Control of adult stem cell function by bioengineered artificial niches

Matthias Lütolf

Stem cells are characterized by their dual ability to self- renew and differentiate, yielding essentially unlimited numbers of progeny that can replenish tissues with either high turnover such as blood and skin or contribute to the regeneration of organs w ...

Imperial College Press2008

Three-dimensional Tip Electrode Array Technology for High Resolution Neuro-Electronic System used in Electrophysiological Experiments in-vitro

Alexandre Schmid, Yusuf Leblebici, Neil Joye, Maurizio Lavagnino

A three-dimensional tip electrode array technology for in- vitro electrophysiological experiments is presented. Based on simulation results obtained with a finite element model of the neuron-electrode interface, it has been shown that the electrical coupli ...

2008

Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

Patrick Schorderet

The therapeutic potential of embryonic stem cells (ESc) is a key scientific interest, but the ethical implications of stem cell research have been controversial and are often a major detriment to the advancement of our knowledge. Recently, several landmark ...

2008

Control of the adaptive response of the heart to stress via the Notch1 receptor pathway

Freddy Radtke, Mario Gaetano Lepore

In the damaged heart, cardiac adaptation relies primarily on cardiomyocyte hypertrophy. The recent discovery of cardiac stem cells in the postnatal heart, however, suggests that these cells could participate in the response to stress via their capacity to ...

2008

Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow

Jean-Jacques Meister, Sébastien Schaub

Dynamic actin network at the leading edge of the cell is linked to the extracellular matrix through focal adhesions (FAs), and at the same time it undergoes retrograde flow with different dynamics in two distinct zones: the lamellipodium (peripheral zone o ...

Public Library of Science2008

Cellular mechanisms regulating adult neurogenesis and olfactory perception in mice

Maria del Carmen Sandi Perez, Thomas Brionne

In the adult mammalian brain, neural stem cells persist in the subventricular zone and the hippocampus, producing new functional neurons throughout life. Whether and how adult neurogenesis maintains brain function remains highly debated. This question is o ...

EPFL2007

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.