In chemistry, neutralization or neutralisation (see spelling differences) is a chemical reaction in which acid and a base react with an equivalent quantity of each other. In a reaction in water, neutralization results in there being no excess of hydrogen or hydroxide ions present in the solution. The pH of the neutralized solution depends on the acid strength of the reactants. In the context of a chemical reaction the term neutralization is used for a reaction between an acid and a base or alkali. Historically, this reaction was represented as acid + base (alkali) → salt + water For example: HCl + NaOH → NaCl + H2O The statement is still valid as long as it is understood that in an aqueous solution the substances involved are subject to dissociation, which changes the ionization state of the substances. The arrow sign, →, is used because the reaction is complete, that is, neutralization is a quantitative reaction. A more general definition is based on Brønsted–Lowry acid–base theory. AH + B → A + BH Electrical charges are omitted from generic expressions such as this, as each species A, AH, B, or BH may or may not carry an electrical charge. Neutralization of sulfuric acid provides a specific example. Two partial neutralization reactions are possible in this instance. H2SO4 + OH− → HSO4− + H2O HSO4− + OH− → SO42− + H2O Overall: H2SO4 + 2 OH− → SO42−+ 2 H2O After an acid AH has been neutralized there are no molecules of the acid (or hydrogen ions produced by dissociation of the molecule) left in solution. When an acid is neutralized the amount of base added to it must be equal to the amount of acid present initially. This amount of base is said to be the equivalent amount. In a titration of an acid with a base, the point of neutralization can also be called the equivalence point. The quantitative nature of the neutralization reaction is most conveniently expressed in terms of the concentrations of acid and alkali.

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