Concept

Depolarization

Related publications (58)

Glucose and lactate are equally effective in energizing activity-dependent synaptic vesicle turnover in purified cortical neurons

This study examines the role of glucose and lactate as energy substrates to sustain synaptic vesicle cycling. Synaptic vesicle turnover was assessed in a quantitative manner by fluorescence microscopy in primary cultures of mouse cortical neurons. An elect ...

Elsevier2006

Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity

Boris Hinz, Michael David Martin

During wound healing and fibrocontractive diseases fibroblasts acquire a smooth muscle cell-like phenotype by differentiating into contractile force generating myofibroblasts. We examined whether regulation of myofibroblast contraction in granulation tissu ...

Wiley-Blackwell2006

Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors

Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...

2006

PhotoMEA: a new optical biosensor for the study of the functional properties of neuronal networks

Diego Ghezzi

Technological innovations in the fields of biomedical optics and electronics have lead to an extremely high level of miniaturization. These steps opened important perspectives to interface optoelectronic instruments with cellular systems. In this frame, a ...

2006

Statistics of subthreshold neuronal voltage fluctuations due to conductance-based synaptic shot noise

Wulfram Gerstner

Neurons in the central nervous system, and in the cortex in particular, are subject to a barrage of pulses from their presynaptic populations. These synaptic pulses are mediated by conductance changes and therefore lead to increases or decreases of the neu ...

2006

Calcium dynamics and intercellular communication in arterial smooth muscle cells

Mathieu Lamboley

This thesis is a contribution to the field of cellular communication in arteries during vasomotion, i.e. rhythmic and spontaneous diameter oscillations of arteries. Investigating how individual smooth muscle cells (SMCs) and endothelial cells (ECs) calcium ...

EPFL2005

Noise and the PSTH response to current transients: I. General theory and application to the integrate-and-fire neuron

Wulfram Gerstner

An analytical model is proposed that can predict the shape of the poststimulus time histogram (PSTH) response to a current pulse of a neuron subjected to uncorrelated background input. The model is based on an explicit description of noise in the form of a ...

2001

Spatiotemporal characterization of rhythmic activity in rat spinal cord slice cultures

Philippe Renaud, Marc Olivier Heuschkel

Rat spinal networks generate a spontaneous rhythmic output directed to motoneurons under conditions of increased excitation or of disinhibition. It is not known whether these differently induced rhythms are produced by a common rhythm generator. To investi ...

2001

Surface dynamics of aerolysin on the plasma membrane of living cells

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Aerolysin secreted by the human pathogen Aeromonas hydrophila belongs to a group of bacterial toxins that are hemolytic and form channels in biological membranes. The toxin is secreted as an inactive precursor proaerolysin that must be proteolytically proc ...

2000

Measurement of the open loop plasma equilibrium response in TCV

Jonathan Bryan Lister

A new technique and results are presented for the estimation of the open loop frequency response of the plasma on TCV. Voltages were applied to poloidal field coils and the resulting plasma current, position and shape related parameters were measured. The ...

1999

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