Publications related to Ischemia-reperfusion injury of the appendicular musculoskeletal system

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Johan Auwerx, Kristina Schoonjans, Qi Wang

The role and underlying mechanism of plasma membrane-bound G protein-coupled bile acid receptor (TGR5) in regulating macrophage innate immune activation during liver ischemia and reperfusion (IR) injury remains largely unclear. Here, we demonstrated that T ...

2020

Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice

Dmitri Firsov, Hikari Ananda Infinity Yoshihara, Jean-Luc Barras, Nicolas Dattner

Aim Arginase 2 (ARG2) is a mitochondrial enzyme that catalyses hydrolysis ofl-arginine into urea andl-ornithine. In the kidney, ARG2 is localized to the S3 segment of the proximal tubule. It has been shown that expression and activity of this enzyme are up ...

WILEY2020

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

Maartje Martina Cornelia Bastings

Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the antiapoptotic, proangiogenic, microRNA (miRNA) cargo within the stem cell ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Hongxia Lei, Lara Buscemi Estefanell

Despite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high-field H-1 MR Spectroscopy ...

2020

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice

Michele De Palma, Mario Leonardo Squadrito, Magdalena Maria Zak

Microvascular dysfunction and resulting tissue hypoxia is a major contributor to the pathogenesis and evolution of cardiovascular diseases (CVD). Diverse gene and cell therapies have been proposed to preserve the microvasculature or boost angiogenesis in C ...

MARY ANN LIEBERT, INC2019

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Jonas Alfred Karl Wilbs

Myocardial ischemia reperfusion (I/R) injury contributes to almost half of the necrotic area after myocardial infarction. To date there is no approved drug to prevent or reduce myocardial I/R injury. The study and understanding of the pathophysiological me ...

JOURNAL OF VISUALIZED EXPERIMENTS2018

The formulation of hyperpolarized 13C pyruvate solutions influences the labeling of myocardial metabolites in vivo

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara

In developing an intact rat model for myocardial ischemia using hyperpolarized 13C pyruvate, different compound formulations were evaluated. Infusion of 4-hydroxy-TEMPO-polarized sodium [1-13C]pyruvate was compared to an equivalent dose of buffered trityl ...

2016

JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro

Tatiana Favez

Mitogen-activated protein kinases (MAPKs) are key regulators that have been linked to cell survival and death. Among the main classes of MAPKs, c-jun N-terminal kinase (JNK) has been shown to mediate cell stress responses associated with apoptosis. In Vitr ...

Springer Int Publishing Ag2016

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Ischemia-reperfusion injury of the appendicular musculoskeletal system

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice

Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice

Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

The formulation of hyperpolarized 13C pyruvate solutions influences the labeling of myocardial metabolites in vivo

JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro

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Chat with Graph Search

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice

Renal tubular arginase-2 participates in the formation of the corticomedullary urea gradient and attenuates kidney damage in ischemia-reperfusion injury in mice

The formulation of hyperpolarized 13C pyruvate solutions influences the labeling of myocardial metabolites in vivo

JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro