Publications related to Broad-spectrum antibiotic

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Camille Véronique Bernadette Goemans, Florian Huber

By acquiring or evolving resistance to one antibiotic, bacteria can become resistant to a second one, due to shared underlying mechanisms. This is called cross-resistance (XR) and further limits therapeutic choices. The opposite scenario, in which initial ...

2024

Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform

Sandor Kasas, Anthony Vocat, Gino Cathomen, Eric Delarze, Florian Tagini, Laura Munch

Antimicrobial resistance (AMR) is a major public health threat, reducing treatment options for infected patients. AMR is promoted by a lack of access to rapid antibiotic susceptibility tests (ASTs). Accelerated ASTs can identify effective antibiotics for t ...

Nature Portfolio2024

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

John McKinney, Neeraj Dhar, Zela Alexandria-Mae Martin

A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded 'mycobacterial ...

Cambridge2023

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots

Francesco Stellacci, Inyoung Yonah Lee

Infections caused by multidrug-resistant (MDR) bacteria pose an impending threat to humanity, as the evolution of MDR bacteria outpaces the development of effective antibiotics. In this work, we use indium phosphide (InP) quantum dots (QDs) to treat infect ...

ROYAL SOC CHEMISTRY2022

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Henning Paul-Julius Stahlberg, Dongchun Ni, Iwan Zimmermann, Denis Bucher

Lipopolysaccharides are major constituents of the extracellular leaflet in the bacterial outer membrane and form an effective physical barrier for environmental threats and for antibiotics in Gram-negative bacteria. The last step of LPS insertion via the L ...

2022

The Dynamics of Single-Cell Nanomotion Behaviour of Saccharomyces cerevisiae in a Microfluidic Chip for Rapid Antifungal Susceptibility Testing

Sandor Kasas, María Inés Villalba

The fast emergence of multi-resistant pathogenic yeasts is caused by the extensive-and sometimes unnecessary-use of broad-spectrum antimicrobial drugs. To rationalise the use of broad-spectrum antifungals, it is essential to have a rapid and sensitive syst ...

MDPI2022

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

Suliana Manley, Luc Reymond, Chen Zhang, Ophélie Rutschmann, Willi Leopold Stepp, Faustine Ambroisine Charline Ryckebusch, Juliette Griffie, Jiangtao Qiao

Fluorescent D-amino acids (FDAAs) have previ-ously been developed to enable in situ highlighting of locations of bacterial cell wall growth. Most bacterial cells lie at the edge of the diffraction limit of visible light; thus, resolving the precise details ...

AMER CHEMICAL SOC2022

Solar water purification with photocatalytic nanocomposite filter based on TiO2 nanowires and carbon nanotubes

László Forró, Luca Rossi, Endre Horvath, Florian Frédéric Vincent Breider, Andrzej Sienkiewicz, Dominique Grandjean, Miriam Gaál

Water contamination due to environmental conditions and poor waste management in certain areas of the world represents a serious problem in accessing clean and safe drinking water. This problem is especially critical in electricity-poor regions, where adva ...

2022

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

John McKinney, Neeraj Dhar, Vivek Vijay Thacker, François Signorino-Gelo, Kunal Sharma, Thomas Marie Simonet

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells to form intracellular bacterial communities (IBCs) during early stages of urinary tract infections. However, the dynamic responses of IBCs to host stresses and anti ...

2021

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Broad-spectrum antibiotic

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

The Dynamics of Single-Cell Nanomotion Behaviour of Saccharomyces cerevisiae in a Microfluidic Chip for Rapid Antifungal Susceptibility Testing

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

Solar water purification with photocatalytic nanocomposite filter based on TiO2 nanowires and carbon nanotubes

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

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Chat with Graph Search

The Dynamics of Single-Cell Nanomotion Behaviour of Saccharomyces cerevisiae in a Microfluidic Chip for Rapid Antifungal Susceptibility Testing

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

Solar water purification with photocatalytic nanocomposite filter based on TiO2 nanowires and carbon nanotubes

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots