Concept

Proteomics

Related publications (173)

High-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century

Yury Tsybin, Anton Kozhinov, Luca Fornelli, Aleksey Vorobyev, Sasa Miladinovic

Mass spectrometry-based qualitative and quantitative (bio)molecular analysis is a corner stone in the state-of-the-art pipelines in systems biology and environmental sciences. High-resolution and efficient tandem mass spectrometry methods and techniques ar ...

Schweizerische Chemische Gesellschaft2011

Microchannel-guided capture antibody patterning on beads for multiple protein detection arrays

Martinus Gijs, Hüseyin Cumhur Tekin, Venkataragavalu Sivagnanam, Sébastien Vaneberg

We present the rapid fabrication of custom protein micro-arrays, in less than 35 minutes, on the surface of immobilized beads using microchannel-guided flows driven by a single syringe pump. The commercially available beads provide robust micro-array surfa ...

2011

Towards data acquisition throughput increase in Fourier transform mass spectrometry of proteins using double frequency measurements

Yury Tsybin, Aleksey Vorobyev

Combined with high and ultra high pressure liquid chromatography, mass spectrometry-based peptide and protein structure analysis requires high resolution and mass accuracy achievable within short ion detection time. Although Fourier transform ion cyclotron ...

Elsevier2011

Microfluidic device for analysis of protein biomarkers using magnetic bead surface coverage detection

Martinus Gijs, Hüseyin Cumhur Tekin, Cynthia Scherz

We present a microfluidic device for on-chip analysis of low-concentration protein biomarkers. A new detection method, based on the magnetic capture of proteins via superparamagnetic beads and counting the surface coverage of the latter is presented. The p ...

2011

Host genetics and HIV-1: the final phase?

Jacques Fellay, Amalio Telenti

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral ...

2010

Polymer Brushes as Substrates for Microarray Applications

Raphaël Barbey

The development of innovative bioanalytical technologies that enable the discovery of new therapeutics or the creation of systems for rapid, accurate and parallel analyses has gained an extraordinary interest in the biomedical sector in the last 10-15 year ...

EPFL2010

Electrochemical and Electrokinetic Tools for Surface Activity Characterization and Proteomics Analysis

Fernando Cortes Salazar

Scanning electrochemical microscopy (SECM) has developed into an excellent and versatile technique to image heterogeneous chemical reactivities on a surface. Therefore SECM applications cover a wide range of different fields such as biology and forensic sc ...

EPFL2010

Mass Spectrometry Based Analysis and Bioanalysis

Hongyan Bi

MS (mass spectrometry) has been developed as an important analytical tool to study large molecules including polymer macromolecules and proteins. Its instrumentation technique including ionization methods, mass analyzer and detector systems has been greatl ...

EPFL2010

Real-Time Bioluminescence Imaging of Glycans on Live Cells

Cell-surface glycans are attractive targets for molecule imaging due to their reflection of cellular processes associated with development and disease progression. In this paper, we describe the design, synthesis, and biological application of a new phosph ...

American Chemical Society2010

How to obtain labeled proteins and what to do with them

Kai Johnsson, Marlon Hinner

We review new and established methods for the chemical modification of proteins in living cells and highlight recent applications. The review focuses on tag-mediated protein labeling methods, such as the tetracysteine tag and SNAP-tag, and new developments ...

Elsevier2010

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