Concept
Estrogen receptor alpha
Related publications (73)
Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium
Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...
EPFL2024Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!
Cathrin Brisken, Carlos Henrique Venturi Ronchi
The presurgical window of opportunity trial (WOT) MIPRA provides evidence that neoadjuvant treatment with the prog-esterone receptor (PR) antagonist mifepristone (RU486) may benefit patients with estrogen receptor-positive (ER+) breast cancer characterized ...
AMER ASSOC CANCER RESEARCH2023Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence
Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Yueyun Zhang, Hazel Margaret Quinn, Kelly Spry Maggs, Patrik Aouad, Fabio De Martino, Céline Marie Victoria Stibolt
More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease remain elusive due to lack of adequate in vivo m ...
2022Estrogen receptor signaling in the human breast epithelium
Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...
EPFL2022A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...
NATURE PORTFOLIO2022Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation
Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investigated geno ...
OXFORD UNIV PRESS2021Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment
Compared to estrogen receptor-negative (ER-) breast cancer (BC), ER+ BC often manifests with a latent disease that recurs decades after initial diagnosis. The mechanisms governing dormancy and distant recurrence of ER+ tumors remain elusive due to the lack ...
EPFL2021Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Cathrin Brisken, Giovanna Ambrosini, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Philipp Bucher, Maryse Fiche, Valentina Scabia, Patrik Aouad, Fabio De Martino
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast cancers but the molecul ...
2021