Concept

Efflux (microbiology)

Related publications (18)

Homogeneous vs. heterogeneous photo-Fenton elimination of antibiotic-resistant bacteria bearing intracellular or extracellular resistance: Do resistance mechanisms interfere with disinfection pathways?

César Pulgarin, Stefanos Giannakis, Truong-Thien Melvin Le, Jérémie Decker

The present study aimed to fill the knowledge gap between the implications of intracellular and extracellular antibiotic resistance mechanisms may inflict on the inactivation pathways of the photo-Fenton process under mild conditions. It was thus designed ...

London2024

In vitro synergistic action of TAT-RasGAP 317-326 peptide with antibiotics against Gram-negative pathogens

Grazia Vizzarro

Objectives: Multidrug-resistant (MDR) bacteria are a continuously increasing threat for medicine, caus-ing infections recalcitrant to antibiotics. Antimicrobial peptides (AMPs) were identified as alternatives to antibiotics, being naturally occurring short ...

ELSEVIER SCI LTD2022

A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo

Mark Austin Hanson

Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading microbes. These short immune effectors are conserved in plants, animals, and fungi. Early work showed that AMPs killed bacteria in generalist fashions in vitro: i.e. AMPs that ...

EPFL2022

Presence of sub-inhibitory concentrations of quaternary ammonium compounds in water: effects on bacteria and their inactivation by ozone and monochloramine

Margaux Océane Voumard

Disinfection agents have been present in our daily lives for several decades in detergents or in personal care products, where their role is to prevent the spread of pathogenic microor-ganisms. One of the largest class of disinfection agents is quaternary ...

EPFL2021

Variability in arsenic methylation efficiency across aerobic and anaerobic microorganisms

Rizlan Bernier-Latmani, Karin Lederballe Meibom, Karen Elda Viacava Romo, Arnaud Michel Gelb, Leia Soraya Véronique Falquet, Shannon Eliot Dyer, Adrien Mestrot

Microbially-mediated methylation of arsenic (As) plays an important role in the As biogeochemical cycle, particularly in rice paddy soils where methylated As, generated microbially, is translocated into rice grains. The presence of the arsenite (As(III)) m ...

2020

Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

Bruno Lemaitre, Camilla Carla Alma Ceroni, Mark Austin Hanson, Anna Dostalova

Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading microorganisms. These short, cationic peptides have been implicated in many biological processes, primarily involving innate immunity. In vitro studies have shown AMPs kill bac ...

Cambridge University Press2019

Population Structure, Molecular Epidemiology, and beta-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States

Luciano Andres Abriata

Stenotrophomonas maltophilia is a Gram-negative, nonfermenting, environmental bacillus that is an important cause of nosocomial infections, primarily associated with the respiratory tract in the immunocompromised population. Aiming to understand the popula ...

2019

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

Henning Paul-Julius Stahlberg

The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution cryo-EM ...

Proceedings of the National Academy of Sciences2018

Mechanistic insight into mycobacterial MmpL protein function

Stewart Cole, Edina Rita Székely

Mycobacterial cell walls are complex structures containing a broad range of unusual lipids, glycolipids and other polymers, some of which act as immunomodulators or virulence determinants. Better understanding of the enzymes involved in export processes wo ...

Wiley-Blackwell2016

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

Gerardo Turcatti, Marc Chambon, Julien Bortoli Chapalay

Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation- ...

Nature Publishing Group2016

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