Concept

Tryptophan

Related publications (39)

Scanning tunneling microscopy on large bio-molecular systems on surfaces

The ever growing demand for the development of new technologies and materials has led to extensive studies inspired by biological functional complexes. Peptides with their outstanding ability to efficiently self-assemble can express a broad spectrum of int ...

EPFL2017

Mechanistic study of the radical SAM-dependent amine dehydrogenation reactions

Xinjian Ji, Shuguang Yuan, Qixing Zhang, Yue Yin

The radical SAM enzyme NosL catalyzes the conversion of L-Trp to 3-methyl-2-indolic acid, and this reaction is initiated by the 5'-deoxyadenosyl (dAdo) radical-mediated hydrogen abstraction from the L-Trp amino group. We demonstrate here that when D-Trp wa ...

Royal Soc Chemistry2016

Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans

Yunfei Huang

Objective: Plasma kynurenine/tryptophan ratio, a biomarker of indoleamine 2,3-dioxygenase-1 (IDO) activity, is a strong independent predictor of mortality in HIV-infected Ugandans initiating antiretroviral therapy (ART) and may play a key role in HIV patho ...

Lippincott Williams & Wilkins2016

The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

Stewart Cole, Florence Pojer

The cyclic AMP-dependent transcriptional regulator GlxR from Corynebacterium glutamicum is a member of the super-family of CRP/FNR (cyclic AMP receptor protein/fumarate and nitrate reduction regulator) transcriptional regulators that play central roles in ...

Public Library of Science2014

Engineering of Ru(II) dyes for interfacial and light-harvesting optimization

Michael Graetzel, Mohammad Khaja Nazeeruddin, Filippo de Angelis, Kuan-Lin Wu, Gabriele Marotta

A new Ru(II) dye, Ru(L1)(L2) (NCS)(2), L1 = (4-(5-hexylthiophen-2-yl)-4'(4-carboxyl-phenyl 2,2'-bipyridine) and L2 = (4-4'-dicarboxy-2,2'- bipyridine), labelled MC112, based on a dissymmetric bipyridine ligand for improved interfacial and optical propertie ...

Royal Society of Chemistry2014

Ultrafast Tryptophan-to-Heme Electron Transfer in Myoglobins Revealed by UV 2D Spectroscopy

Majed Chergui, Frank van Mourik, Cristina Consani

Tryptophan is commonly used to study protein structure and dynamics, such as protein folding, as a donor in fluorescence resonant energy transfer (FRET) studies. By using ultra-broadband ultrafast two-dimensional (2D) spectroscopy in the ultraviolet (UV) a ...

American Association for the Advancement of Science2013

Coherent manipulation of free amino acids fluorescence

Christoph Peter Hauri

Coherent manipulation of molecular wavepackets in biomolecules might contribute to the quest towards label-free cellular imaging and protein identification. We report the use of optimally tailored UV laser pulses in pump-probe depletion experiments that se ...

2012

Structure, Dynamics and Thermodynamics of the Human Centrin 2/hSfi1 Complex

Geoffrey Bodenhausen, Daniel Abergel

Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of centrosomes, and Sfi1 (Suppressor of fermentation-induced loss of stress resistance protein 1) is one of its centrosomal targets. There are three isoforms of h ...

Elsevier2010

Photophysics and Photochemistry from First Principles

Matteo Guglielmi

Quantum chemical methods are important tools for the predictions of electronic structure and energetics of molecules providing the interpretation of spectroscopic experiments and reaction mechanisms. In this thesis, density functional theory (DFT) and wave ...

EPFL2010

Functional electric field changes in photoactivated proteins revealed by ultrafast Stark spectroscopy of the Trp residues

Majed Chergui, Frank van Mourik, Andrea Cannizzo, Erwin Portuondo Campa, Stefan Haacke

Ultrafast transient absorption spectroscopy of wild-type bacteriorhodopsin (WT bR) and 2 tryptophan mutants (W86F and W182F) is performed with visible light excitation (pump) and UV probe. The aim is to investigate the photoinduced change in the charge dis ...

2009

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