The Potomac River (pəˈtoʊmək) is a major river in the Mid-Atlantic region of the United States that flows from the Potomac Highlands in West Virginia to the Chesapeake Bay in Maryland. It is long, with a drainage area of 14,700 square miles (38,000 km2), and is the fourth-largest river along the East Coast of the United States and the 21st-largest in the United States. Over 5 million people live within its watershed.
The river forms part of the borders between Maryland and Washington, D.C., on the left descending bank, and West Virginia and Virginia on the right descending bank. Except for a small portion of its headwaters in West Virginia, the North Branch Potomac River is considered part of Maryland to the low-water mark on the opposite bank. The South Branch Potomac River lies completely within the state of West Virginia except for its headwaters, which lie in Virginia.
The Potomac River runs from Fairfax Stone Historical Monument State Park in West Virginia on the Allegheny Plateau to Point Lookout, Maryland, and drains . The length of the river from the junction of its North and South Branches to Point Lookout is .
The river has two sources. The source of the North Branch is at the Fairfax Stone located at the junction of Grant, Tucker, and Preston counties in West Virginia. The source of the South Branch is located near Hightown in northern Highland County, Virginia. The river's two branches converge just east of Green Spring in Hampshire County, West Virginia, to form the Potomac. As it flows from its headwaters down to the Chesapeake Bay, the Potomac traverses five geological provinces: the Appalachian Plateau, the Ridge and Valley, the Blue Ridge, the Piedmont Plateau, and the Atlantic coastal plain.
Once the Potomac drops from the Piedmont to the Coastal Plain at the Atlantic Seaboard fall line at Little Falls, tides further influence the river as it passes through Washington, D.C., and beyond. Salinity in the Potomac River Estuary increases thereafter with distance downstream.