Publications related to Peroxisome proliferator-activated receptor

PPAR delta Promotes Running Endurance by Preserving Glucose

Johan Auwerx, Hao Li, Vincenzo Sorrentino

Management of energy stores is critical during endurance exercise; a shift in substrate utilization from glucose toward fat is a hallmark of trained muscle. Here we show that this key metabolic adaptation is both dependent on muscle PPAR delta and stimulat ...

Cell Press2017

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Rosario Scopelliti, Johannes Broichhagen

Drugs that allosterically modulate G protein-coupled receptor (GPCR) activity display higher specificity and may improve disease treatment. However, the rational design of compounds that target the allosteric site is difficult, as conformations required fo ...

Wiley-V C H Verlag Gmbh2017

Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models

Vassily Hatzimanikatis, Bart Deplancke, Alina Isakova, Yves Berset

Many transcription factors (TFs) have the ability to cooperate on DNA elements as heterodimers. Despite the significance of TF heterodimerization for gene regulation, a quantitative understanding of cooperativity between various TF dimer partners and its i ...

American Society for Biochemistry and Molecular Biology2016

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Johan Auwerx, Eija Riitta Pirinen

PPAR gamma-dependent gene expression during adipogenesis is facilitated by ADP-ribosyltransferase D-type 1 (ARTD1; PARP1)-catalyzed poly-ADP-ribose (PAR) formation. Adipogenesis is accompanied by a dynamic modulation of the chromatin landscape at PPAR gamm ...

Oxford University Press2015

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu, Xu Wang, Adriano Maida

Nuclear receptor corepressor 1 (NCoR1) is a transcriptional coregulator that has wide-ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits activation of peroxisome proliferator ...

Wiley-Blackwell2015

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis

Kristina Schoonjans, Matthias Alexander Sokrates Stein

Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involvi ...

Nature Publishing Group2015

How many lives does CLIMP-63 have?

Françoise Gisou van der Goot Grunberg, Patrick Alain Sandoz

In 1995, in the Biochemical Society Transactions, Mundy published the first review on CLIMP-63 (cytoskeletonlinking membrane protein 63) or CKPA4 (cytoskeleton-associated protein 4), initially just p63 [1]. Here we review the following 20 years of research ...

2015

Johan Auwerx

The estrogen-related receptor- (ERR) regulates mitochondrial biogenesis and glucose and fatty acid oxidation during differentiation in skeletal myocytes. However, whether ERR controls metabolic remodeling during skeletal muscle regeneration in vivo is unkn ...

Federation of American Society of Experimental Biology2014

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Peroxisome proliferator-activated receptor

Autophagy regulates lipid metabolism through selective turnover of NCoR1

PPAR delta Promotes Running Endurance by Preserving Glucose

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis

How many lives does CLIMP-63 have?

Estrogen-related receptor-alpha ( ERR alpha) deficiency in skeletal muscle impairs regeneration in response to injury

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Chat with Graph Search

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Autophagy regulates lipid metabolism through selective turnover of NCoR1

PPAR delta Promotes Running Endurance by Preserving Glucose

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

How many lives does CLIMP-63 have?

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR gamma ligand synthesis

Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

Estrogen-related receptor-alpha ( ERR alpha) deficiency in skeletal muscle impairs regeneration in response to injury