Publications related to Brain-derived neurotrophic factor

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Rolf Gruetter, Lijing Xin, Kim Do, Benoît Schaller, Huanxiang Lu

BACKGROUND: Oxidative stress and glutathione (GSH) metabolism dysregulation has been implicated in the pathophysiology of schizophrenia. GAG-trinucleotide repeat (TNR) polymorphisms in the glutamate-cysteine ligase catalytic gene (GCLC), the rate-limiting ...

Oxford University Press2016

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

Silvestro Micera, Daniel Santos

Neurotrophic factors (NTFs) promote nerve regeneration and neuronal survival after peripheral nerve injury. However, drawbacks related with administration and bioactivity during long periods limit their therapeutic application. In this study, PLGA microsph ...

Elsevier Science Bv2016

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Patrick Fraering, Mitko Dimitrov, Hermeto Gerber, Maria Luna Perciato, Jingjing Chen, Andrea Rinaldi

Activation of NOTCH signalling is associated with advanced prostate cancer and treatment resistance in prostate cancer patients. However, the mechanism that drives NOTCH activation in prostate cancer remains still elusive. Moreover, preclinical evidence of ...

Nature Publishing Group2016

Differential effects of BDNF val(66)met in repetitive associative learning paradigms

Friedhelm Christoph Hummel, Winifried Backhaus

In healthy young subjects, the brain derived neurotropic factor (BDNF) val(66)met polymorphism negatively affects behavioural outcome in short-term motor cortex or hippocampus-based learning paradigms. In repetitive training paradigms over several days thi ...

Elsevier2015

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic understanding is still lacking. However, neurodegenerative diseases such as Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) al ...

Bentham Science Publishers2015

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

Pierre Magistretti, Jean-Luc Martin, Benjamin Boutrel, Benjamin Boury-Jamot, Anthony Carrard

A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memo ...

Nature Publishing Group2015

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

Bernard Schneider, Graham Knott, Wojciech Janusz Bobela, Lu Zheng

Introduction: Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1 alpha, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as ...

Biomed Central Ltd2015

Stroking or Buzzing? A Comparison of Somatosensory Touch Stimuli Using 7 Tesla fMRI

Rolf Gruetter, Wietske Van der Zwaag, Roberto Martuzzi

Studying body representations in the brain helps us to understand how we humans relate to our own bodies. The in vivo mapping of the somatosensory cortex, where these representations are found, is greatly facilitated by the high spatial resolution and high ...

Public Library of Science2015

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

Graham Knott, Bohumil Maco

The appearance and disappearance of dendritic spines, accompanied by synapse formation and elimination may underlie the experience-dependent reorganization of cortical circuits. The exact temporal relationship between spine and synapse formation in vivo re ...

Soc Neuroscience2014

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Brain-derived neurotrophic factor

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions

Differential effects of BDNF val(66)met in repetitive associative learning paradigms

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

Stroking or Buzzing? A Comparison of Somatosensory Touch Stimuli Using 7 Tesla fMRI

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

Graph Chatbot

Chat with Graph Search

Genetic Polymorphism Associated Prefrontal Glutathione and Its Coupling With Brain Glutamate and Peripheral Redox Status in Early Psychosis

Differential effects of BDNF val(66)met in repetitive associative learning paradigms

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

Stroking or Buzzing? A Comparison of Somatosensory Touch Stimuli Using 7 Tesla fMRI

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions

Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases