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A subpopulation of familial cases of amyotrophic lateral sclerosis has been linked to mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). There is in vitro evidence that certain SOD1 mutants, in addition to their normal dismutation function, ...
Zinc(II) phthalocyanine (ZnPC) is a new photosensitizer currently undergoing phase I and II clinical trials at Lausanne's CHUV hospital for the photodynamic therapy (PDT) of early cancer in the upper aerodigestive tract. Activated oxygen species other than ...
A group of receptors termed peroxisome proliferator activated receptors (PPAR), belonging to the nuclear hormone receptor supergene family, might be crucial in explaining how a diverse group of apparently unrelated chemicals induce peroxisomal proliferatio ...
A series of mutants bearing single amino acid substitutions often encountered in the catalase/peroxidase, KatG, from isoniazid-resistant isolates of Mycobacterium tuberculosis has been produced by site-directed mutagenesis. The resultant enzymes were overe ...
Synthetic boron doped diamond electrodes and microelectrodes were manufd. with techniques usually utilized in microelectronics: HFCVD coating, optical photolithog. and plasma etching. These electrodes were characterized in terms of their electrochem. prope ...
Benzoporphyrin deriv. monoacid ring A [BPD-MA (I)], a chlorin-type mol., is a new photosensitizer currently in phase II clin. trials for the treatment by photodynamic therapy of cancerous lesions, psoriasis and pathol. neovascularization. The photochem. (t ...
Kinetic simulations have been tested by laboratory experiments to evaluate the major factors controlling bromate formation during ozonation of waters containing bromide. In the presence of an organic scavenger for OH radicals, bromate formation can be accu ...
Contributions of radical and non-radical processes have been determined in the formation of radiolysis products of n-heptane, n-octane, n-nonane and n-decane in a large range of temperature. Calculations are based on the combination and the dismutation of ...
In the flash photolysis of Me2Hg, approx. 85% of the Me radicals are produced in excited states. From a study of the relaxation rate in various gases, i.e. He, Ar, O2, it is evident that the free radicals are excited vibrationally and it is suggested that ...
