Concept

Anal cancer

Related publications (70)

Notch1 can contribute to viral-induced transformation of primary human keratinocytes

The human papillomavirus (HPV) is the most significant causative agent in the development of cervical cancer. Despite its presence in almost all cervical cancers, HPV by itself is unable to transform a normal cell to a cancerous one. Instead, additional ce ...

2003

In vivo autofluorescence spectroscopy of human bronchial tissue to optimize the detection and imaging of early cancers

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

We are developing an imaging system to detect pre-/early cancers in the tracheo-bronchial tree. Autofluorescence might be useful but many features remain suboptimal. We have studied the autofluorescence of human healthy, metaplastic and dysplastic/CIS bron ...

2001

Lymphatic function, lymphangiogenesis, and cancer metastasis

Melody Swartz

The lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemi ...

2001

Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Pavel Kucera

Exogenous administration of 5-aminolaevulinic acid (ALA) is becoming widely used to enhance the endogenous synthesis of protoporphyrin IX (PpIX) in photodynamic therapy (PDT) and fluorescence photodetection (PD). Recently, results have shown that the chemi ...

1999

Reduced gene expression of E-cadherin and associated catenins in human cervical carcinoma cell lines

Cell-cell adhesion mediated by E-cadherin is often lost or disturbed in human carcinomas. For regular adhesive function, E-cadherin has to form complexes with peripheral cytoplasmic catenins which are multifunctional proteins that are also involved in sign ...

1997

Photodynamic Therapy for Cancer of the Upper Aerodigestive Tract Using Tetra(m-hydroxyphenyl)chlorin

Hubert van den Bergh, Georges Wagnières, Alain Woodtli

A major step in the development of photodynamic therapy (PDT) is the clinical optimization and evaluation of new photosensitizers (PS). Ideally, new compounds should be more effective and/or induce fewer side effects than the first generation PS such as he ...

1996

Involvement of Ifn-Gamma in Bacillus Calmette-Guerin-Induced but Not in Tumor-Induced Sensitization to Tnf-Induced Lethality

Michel Aguet

In healthy mice, murine (m) TNF is fairly lethal, whereas human (h) TNF (a selective murine TNF-R55 agonist) is rather harmless. However, we and others observed that mice suffering from a bacterial infection, such as Bacillus Calmette-Guerin (BCG), or bear ...

1995

Human papillomavirus type 42: new sequences, conserved genome organization.

Stewart Cole

We report the nucleotide sequence and genome organization of the human papillomavirus type 42. HPV42 DNA was isolated from vulvar papillomas. It has been detected in benign forms of proliferative lesions only. The genome of HPV42 is 7917 bp long and shows ...

1992

A member of the activator protein 1 family found in keratinocytes but not in fibroblasts required for transcription from a human papillomavirus type 18 promoter

Peter Martin Beard

Papillomaviruses are tissue specific and replicate in differentiating keratinocytes. We are interested in the question of tissue specificity at the level of transcription. We used extracts from human keratinocytes and human fibroblasts at low passage numbe ...

1990

A single point mutation responsible for c-mos polymorphism in cancer patients.

Stewart Cole

A rare EcoRI restriction fragment length polymorphism (RFLP) in the 3' end of the human c-mos locus has been identified in DNA from patients with breast tumors, esophageal carcinomas and leukemias. Until now, this RFLP has not been found in normal populati ...

1987

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