Concept
Viral entry
Related publications (50)
An Atomistic Look into Bio-inspired Nanoparticles and their Molecular Interactions with Cells
Francesco Stellacci, Alke Fink, Pablo Campomanes Ramos, Stefano Vanni
Nanoparticles (NPs) have sizes that approach those of pathogens and they can interact with the membranes of eukaryotic cells in an analogous fashion. Typically, NPs are taken up by the cell via the plasma membrane by receptor-mediated processes and subsequ ...
SWISS CHEMICAL SOC2019Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Johann Mauron, Joël Oppliger, Maxime Matter, Noémie Oechslin
Hepatitis E virus (HEV) is a positive-strand RNA virus encoding 3 open reading frames (ORF). HEV ORF3 protein is a small, hitherto poorly characterized protein involved in viral particle secretion and possibly other functions. Here, we show that HEV ORF3 p ...
PUBLIC LIBRARY SCIENCE2018Broad-spectrum Antiviral Nanoparticles
Viral infections affect millions of people every year, yet broad-spectrum virucidal therapies are not available. Antiviral substances in current use act on specific viral mechanisms against only a small number of viruses. Virustatic materials interfere wit ...
EPFL2017Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control
Jacques Fellay, Amalio Telenti, Istvan Bartha
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variat ...
Public Library of Science2017Viral RNA Degradation and Diffusion Act as a Bottleneck for the Influenza A Virus Infection Efficiency
After endocytic uptake, influenza viruses transit early endosomal compartments and eventually reach late endosomes. There, the viral glycoprotein hemagglutinin (HA) triggers fusion between endosomal and viral membrane, a critical step that leads to release ...
Public Library Science2016Echovirus 11 mutants with increased resistance to common water disinfectants
Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong
Common water disinfectants like chlorine have been reported to select for resistant viruses. Yet, only little attention has been devoted to characterizing disinfection resistance. The goal of this study was to produce disinfectant-resistant viruses and to ...
2016Echovirus 11 mutants with increased resistance to common water disinfectants
Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Qingxia Zhong
Common water disinfectants like chlorine have been reported to select for resistant viruses. Yet, only little attention has been devoted to characterizing disinfection resistance. The goal of this study was to produce disinfectant-resistant viruses and to ...
2016Human genetic variation in HIV disease: beyond genome-wide association studies
PURPOSE OF REVIEW: Rapid expansion of genomic technologies has resulted in an unprecedented ability to interrogate the impact of human genetic variation on disease. HIV-1 infection is a unique model for studying this impact because host genetic variation i ...
Lippincott Williams & Wilkins2015GuavaH: a compendium of host genomic data in HIV biology and disease
Jacques Fellay, Amalio Telenti, Istvan Bartha
Background: There is an ever-increasing volume of data on host genes that are modulated during HIV infection, influence disease susceptibility or carry genetic variants that impact HIV infection. We created GuavaH (Genomic Utility for Association and Viral ...
BioMed Central2014Force-induced globule-coil transition in laminin binding protein and its role for viral-cell membrane fusion
Giovanni Dietler, Fabrizio Benedetti, Andrey Mikhaylov, Tatyana Karakouz, Denis Korneev
The specific interactions of the pairs laminin binding protein (LBP)-purified tick-borne encephalitis viral surface protein E and certain recombinant fragments of this protein, as well as West Nile viral surface protein E and certain recombinant fragments ...
Wiley-Blackwell2014