Concept

Spike-timing-dependent plasticity

Related publications (256)

Sweet sixteen for ANLS

Since its introduction 16 years ago, the astrocyte-neuron lactate shuttle (ANLS) model has profoundly modified our understanding of neuroenergetics by bringing a cellular and molecular resolution. Praised or disputed, the concept has never ceased to attrac ...

2012

Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury

Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler

Severe spinal cord injury (SCI) permanently abolishes motor functions caudal to the lesion. However, the neuronal machinery sufficient to produce standing and stepping is located below most SCI, and can be reactivated with training. Therefore, why do rats ...

2012

Short-term ionic plasticity at GABAergic synapses

Henry Markram

Fast synaptic inhibition in the brain is mediated by the pre-synaptic release of the neurotransmitter γ-Aminobutyric acid (GABA)and the post-synaptic activation of GABA-sensitive ionotropic receptors. As with excitatory synapses, it is being increasinly ap ...

2012

Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement

Maria del Carmen Sandi Perez, Erika Myrna Borcel Novoa, Lidia Alonso-Nanclares

Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from ...

2012

Hearts and bones': the ups and downs of plasticity' in stem cell biology

Yann Barrandon, Paola Bonfanti

More than a decade ago, plasticity suddenly became a fashionable topic with overemphasized implications for regenerative medicine. The concept of plasticity is supported by old transplantation work, at least for embryonic cells, and metaplasia is a classic ...

Wiley Open Access2012

An epigenetic blockade of cognitive functions in the neurodegenerating brain

Johannes Gräff

Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer's disease. The causes leading to such impairment are only poorly understood and effective treatments are slow to emerge. Here ...

2012

Coding and Decoding with Adapting Neurons: A Population Approach to the Peri-Stimulus Time Histogram

Wulfram Gerstner, Richard Naud

The response of a neuron to a time-dependent stimulus, as measured in a Peri-Stimulus-Time-Histogram (PSTH), exhibits an intricate temporal structure that reflects potential temporal coding principles. Here we analyze the encoding and decoding of PSTHs for ...

Public Library of Science2012

A triplet spike-timing-dependent plasticity model generalizes the Bienenstock-Cooper-Munro rule to higher-order spatiotemporal correlations

Jean-Pascal Théodor Pfister, Claudia Clopath, Juliette Audet

Synaptic strength depresses for low and potentiates for high activation of the postsynaptic neuron. This feature is a key property of the Bienenstock-Cooper-Munro (BCM) synaptic learning rule, which has been shown to maximize the selectivity of the postsyn ...

2011

Interregional synaptic competition in neurons with multiple STDP-inducing signals

Idan Segev

Neocortical layer 5 (L5) pyramidal cells have at least two spike initiation zones: Na+ spikes are generated near the soma, and Ca2+ spikes at the apical dendritic tuft. These spikes interact with each other and serve as signals for synaptic plasticity. The ...

2011

Variational Learning for Recurrent Spiking Networks

Wulfram Gerstner, Danilo Jimenez Rezende, Daniël Pieter Wierstra

We derive a plausible learning rule updating the synaptic efficacies for feedforward, feedback and lateral connections between observed and latent neurons. Operating in the context of a generative model for distributions of spike sequences, the learning me ...

2011

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