Multivariable calculus

Multivariable calculus (also known as multivariate calculus) is the extension of calculus in one variable to calculus with functions of several variables: the differentiation and integration of functions involving multiple variables (multivariate), rather than just one. Multivariable calculus may be thought of as an elementary part of advanced calculus. For advanced calculus, see calculus on Euclidean space. The special case of calculus in three dimensional space is often called vector calculus. Typical operations Limits and continuity A study of limits and continuity in multivariable calculus yields many counterintuitive results not demonstrated by single-variable functions. For example, there are scalar functions of two variables with points in their domain which give different limits when approached along different paths. E.g., the function. :f(x,y) = \frac{x^2y}{x^4+y^2} approaches zero whenever the point (0,0)

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Strong convergence of multivariate maxima

Simone Padoan, Stefano Rizzelli

It is well known and readily seen that the maximum of n independent and uniformly on [0, 1] distributed random variables, suitably standardised, converges in total variation distance, as n increases, to the standard negative exponential distribution. We extend this result to higher dimensions by considering copulas. We show that the strong convergence result holds for copulas that are in a differential neighbourhood of a multivariate generalised Pareto copula. Sklar's theorem then implies convergence in variational distance of the maximum of n independent and identically distributed random vectors with arbitrary common distribution function and (under conditions on the marginals) of its appropriately normalised version. We illustrate how these convergence results can be exploited to establish the almost-sure consistency of some estimation procedures for max-stable models, using sample maxima.

CAMBRIDGE UNIV PRESS2020

Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

Aurélie Delacrétaz, Céline Dubath, Johannes Gräff, Jose Vicente Sanchez Mut

Background: Metabolic side effects induced by psychotropic drugs represent a major health issue in psychiatry. CREB-regulated transcription coactivator 1 (CRTC1) gene plays a major role in the regulation of energy homeostasis and epigenetic mechanisms may explain its association with obesity features previously described in psychiatric patients. This prospective study included 78 patients receiving psychotropic drugs that induce metabolic disturbances, with weight and other metabolic parameters monitored regularly. Methylation levels in 76 CRTC1 probes were assessed before and after 1 month of psychotropic treatment in blood samples. Results: Significant methylation changes were observed in three CRTC1 CpG sites (i.e., cg07015183, cg12034943, and cg 17006757) in patients with early and important weight gain (i.e., equal or higher than 5% after 1 month; FDR p value = 0.02). Multivariable models showed that methylation decrease in cg12034943 was more important in patients with early weight gain (>= 5%) than in those who did not gain weight (p = 0.01). Further analyses combining genetic and methylation data showed that cg12034943 was significantly associated with early weight gain in patients carrying the G allele of rs4808844A>G (p = 0.03), a SNP associated with this methylation site (p = 0.03). Conclusions: These findings give new insights on psychotropic-induced weight gain and underline the need of future larger prospective epigenetic studies to better understand the complex pathways involved in psychotropic-induced metabolic side effects.

BMC2019

Multi-objective optimization of turbo-ORC systems for waste heat recovery on passenger car engines

Eliott Philippe Guenat, Violette Mounier, Kévin Rosset, Jürg Alexander Schiffmann

Waste heat recovery from passenger car internal combustion engines by means of an organic Rankine cycle (ORC) system is promising for reducing CO2 emissions. In this study, different cycle configurations capable of converting waste heat from both coolant and exhaust gases are investigated based on different working fluid categories. Radial-inflow turbines are considered as expansion devices and corresponding isentropic efficiencies are evaluated based on a preliminary design map accounting for the effect of the pressure ratio. Mechanical losses resulting from the use of a gas-bearing-supported rotor driving a permanent magnet generator are also evaluated. In order to identify the turbo-ORC system design tradeoffs, constrained multi-variable and multi-objective optimizations are performed using an evolutionary algorithm. It is found that the optimal cycle configuration and working fluid depend on the available space in the vehicle and that the condenser is the most critical component for the ORC system integration. In addition, the most suitable working fluids for this application are characterized by (1) a boiling point close to the heat sink temperature, (2) a high critical pressure, and (3) a high molecular weight. The resulting optimal radial-inflow turbines are 10e33 mm in tip diameter and operate at 80 e330 krpm.

2018

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