Concept
Juvenile idiopathic arthritis
Related publications (17)
Re-evaluating the mythical divide between traditional and novel cardiovascular risk factors in rheumatoid arthritis
Cardiovascular (CV) risk factors for rheumatoid arthritis (RA) are conventionally classified as 'traditional' and 'novel'. We argue that this classification is obsolete and potentially counterproductive. Further, we discuss problems with the common practic ...
London2024Acoustical Features as Knee Health Biomarkers: A Critical Analysis
David Atienza Alonso, Vincent Stadelmann, Tomas Teijeiro Campo, Jérôme Paul Rémy Thevenot, Christodoulos Kechris
Acoustical knee health assessment has long promised an alternative to clinically available medical imaging tools, but this modality has yet to be adopted in medical practice. The field is currently led by machine learning models processing acoustical featu ...
2024Introducing tolerance to foreign and partly foreign proteins by erythrocyte binding and artificial glycosylations
Over the last few years, protein drugs have steadily gained importance in the clinic. Compared to small molecule drugs, protein drugs are taken up by antigen presenting cells, which degrade the proteins into peptides that are then presented on major histoc ...
EPFL2018Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites
Nicola Harris, Mario Michael Zaiss, Manuel Kulagin
Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severi ...
Taylor & Francis2017Potential blindness in children of patients with hereditary bone disease
Mono- and bi-allelic mutations in the low-density lipoprotein receptor related protein 5 (LRP5) may cause osteopetrosis, autosomal dominant and recessive exudative vitreoretinopathy, juvenile osteoporosis, or persistent hyperplastic primary vitreous (PHPV) ...
Springer London Ltd2016Effects of PVA-coated nanoparticles on human T helper cell activity
Heinrich Hofmann, Lionel André Maurizi
Superparamagnetic iron oxide nanoparticles (SPION) are used as high-sensitive enhancer for magnetic resonance imaging, where they represent a promising tool for early diagnosis of destructive diseases such as rheumatoid arthritis (RA). Since we could demon ...
Elsevier2016Modification of the surface of superparamagnetic iron oxide nanoparticles to enable their safe application in humans
Heinrich Hofmann, Lionel André Maurizi
Combined individually tailored methods for diagnosis and therapy (theragnostics) could be beneficial in destructive diseases, such as rheumatoid arthritis. Nanoparticles are promising candidates for theragnostics due to their excellent biocompatibility. Na ...
Dove Medical Press Ltd2016The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis
Heinrich Hofmann, Lionel André Maurizi
Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize ...
Public Library of Science2015Effects of PVA coated nanoparticles on human immune cells
Heinrich Hofmann, Lionel André Maurizi
Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed after irreversible joint structural damage has occurred. There is an urgent nee ...
Dove Medical Press Ltd2015Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages
Heinrich Hofmann, Lionel André Maurizi, Géraldine Sylvie Coullerez
Introduction: Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correl ...
Biomed Central Ltd2014