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2-Aryl-2-fluoropropionic acids were prepd. by treatment of either Et a-hydroxycarboxylates or cyanohydrin O-silyl ethers with diethylaminosulfur trifluoride and subsequent hydrolysis. The Me ester of 2-fluoro-2-(4-isobutylphenyl)propionic acid ("a-fluoroi ...
The asym. synthesis of a series of 2-piperidinealkanamines starting from (-)-2-cyano-6-phenyloxazolopiperidine was [i.e., [3R-(3alpha ,5beta ,8abeta )]-hexahydro-3-phenyl-5H-oxazolo[3,2-a]pyridine-5-carbonitrile] (I) as described. LiAlH4 redn. of I followe ...
A photosensitizer complex of formulae (Ia) MX3Lt or (Ib) MXYLt in which M is a transition metal selected from ruthenium, osmium, iron, rhenium and technetium, preferably ruthenium or osmium; each X is a co-ligand independently selected from NCS,Cl,Br,I,CN, ...
The aromatic diacid residue 4,6-dibenzofuranbispropionic acid (1) was designed to nucleate a parallel beta-sheet-like structure in small peptides in aqueous solution via a hydrogen-bonded hydrophobic cluster. Even though a 14-membered ring hydrogen bond ne ...
A compound, in metal-free or metal complex form of formula (1) to (3) in which R is hydrogen or C1-30 alkyl; X is hydrogen, halogen (preferably Cl or Br) or C1-30 alkyl. ...
(Ecole Polytechnique Federale de Lausanne (epfl), Switz.).1995
A novel spiropiperidine system I i.e. an aza structural analog of histrionicotoxin was constructed from 2-cyano-6-phenyloxazolopiperidine synthon II. The suitable quaternary carbon was created by alkylation at the position alpha to the nitrile followed by ...
From 2-cyano-6-phenyloxazolopiperidine, two highly efficient routes have been developed for the asym. synthesis of the spiropiperidine system: 1,8-diazaspiro[5.5]undecane. The key step was generation of the imine salts from the functionalized alpha -amino ...
Oxiranecarbonitrile in basic aq. soln. at room temp. reacts regioselectively with inorg. phosphate to give the cyanohydrin of 2-oxoethyl phosphate ('glycolaldehyde phosphate'), a source of (the hydrate of) the free aldehyde, preferably in the presence of f ...
An adaptation of Kubelka's general model of diffuse reflectance and diffuse transmittance of light to nonideal scattering samples is proposed. It is applied to quant. Fourier transform IR spectrometry of nondiluted surface-derivatized silica powders. Corre ...
