Concept

Reaction intermediate

Related publications (288)

An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries

Droplet-based microfluidic systems allow biological and chemical reactions to be performed on a drastically decreased scale. However, interfacing the outside world with such systems and generating high numbers of microdroplets of distinct chemical composit ...

2010

Morphogenesis of the T4 tail and tail fibers

Petr Leiman

Remarkable progress has been made during the past ten years in elucidating the structure of the bacteriophage T4 tail by a combination of three-dimensional image reconstruction from electron micrographs and X-ray crystallography of the components. Partial ...

BioMed Central2010

Breaking the passivation-the road to a solvent free borohydride synthesis

We describe a new method for the solvent-free synthesis of borohydrides at room temperature and demonstrate its feasibility by the synthesis of three of the most discussed borohydrides at present: LiBH4, Mg(BH 4)2 and Ca(BH4)2. This new gas-solid mechanoch ...

2010

Microstructural development of early age hydration shells around cement grains

Karen Scrivener, Emmanuel Gallucci, Prakash Chandra Mathur

An important microstructural aspect of the early hydration of Portland cement (K) is the formation of a shell of hydration products around cement grains. There is, at present, limited information on the mechanism of formation of the shell and of the chemis ...

2010

Olefin Cyclopropanations via Sequential Atom Transfer Radical Addition-Dechlorination Reactions

Kay Severin, Katrin Anne Thommes

In organic synthesis, cyclopropanation reactions are often performed with Simmons Smith-type reagents or by transition metal catalyzed reactions of olefins with diazo compounds. A novel method for the synthesis of substituted cyclopropanes is described tha ...

2010

First-Principles Study of Non-heme Fe(II) Halogenase SyrB2 Reactivity

Nicola Marzari

We present here a computational study of reactions at a model complex of the SyrB2 enzyme active site. SyrB2, which chlorinates L-threonine in the syringomycin biosynthetic pathway, belongs to a recently discovered class of alpha-ketoglutarate (alpha KG), ...

2009

Enantioselective synthesis of indanols from tert-cyclobutanols using a rhodium-catalyzed C-C/C-H activation sequence

Nicolai Cramer

Tert.-Cyclobutanols were activated through an enantioselective rhodium(I)-catalyzed insertion into the C-C bond leading to arylrhodium species. These intermediates are converted by a C-H activation mechanism to arylrhodium species that are converted to ind ...

Wiley-VCH Verlag GmbH & Co. KGaA2009

Unraveling the Catalytic Pathway of Metalloenzyme Farnesyltransferase through QM/MM Computation

Matteo Dal Peraro

The protein farnesyltransferase (FTase) is a Zn2+-metalloenzyme that catalyzes the farnesylation reaction, i.e., the transfer of the 15-carbon atom farnesyl group from farnesyl diphosphate (FPP) to a specific cysteine of protein substrates. Oncogenic Ras p ...

2009

Microstructural development of calcium aluminate cement based systems with and without supplementary cementitious materials

Christophe Gosselin

Calcium Aluminate Cements (CAC) are renowned in the field of construction for specific applications requiring rapid hardening and chemical resistance. These properties result from rapid exothermic reactions occurring immediately after setting. Due to the m ...

EPFL2009

Micelles for delivery of nitric oxide

Nikolaos Stergiopoulos, Davide Demurtas, Jeffrey Alan Hubbell, Simone Cavadini, Tyler Nerton Thacher, Yun Suk Jo, Jay Gantz

We designed block copolymer pro-amphiphiles and amphiphiles for providing very long-term release of nitric oxide (NO). A block copolymer of N-acryloylmorpholine (AM, as a hydrophile) and N-acryloyl-2,5-dimethylpiperazine (AZd, as a hydrophilic precursor) w ...

2009

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