Concept
Entry inhibitor
Related publications (21)
Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Philippe Colin, Aleksandar Antanasijevic
Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutralizat ...
San Francisco2023Multivalent Virucidal Antivirals: Synthesis, Mechanisms of Action, and Immune-stimulating Effects
Viruses initiate invasion by binding to cell surface glycoproteins. Materials mimicking the carbohydrate motifs of these glycoproteins, such as heparan sulfate (HS) and sialic acid (SA) can block viral attachment and inhibit the infection. Multivalent disp ...
EPFL2023Antiviral Screen against Canine Distemper Virus-Induced Membrane Fusion Activity
Gerardo Turcatti, Marc Chambon, Jonathan Patrice Vesin
Canine distemper virus (CDV), a close relative of the human pathogen measles virus (MeV), is an enveloped, negative sense RNA virus that belongs to the genus Morbillivirus and causes severe diseases in dogs and other carnivores. Although the vaccination i ...
2021Advances in the development of entry inhibitors for sialic-acid-targeting viruses
Francesco Stellacci, Matteo Gasbarri, Özgün Kocabiyik
Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional stra ...
ELSEVIER SCI LTD2021Novel broad-spectrum virucidal antivirals
The current COVID-19 pandemic has showed the threats that viruses can cause to the whole world. Over 200 million infections and over 4.5 million deaths and enormous socio-economic impact were the output of the emergence of a single new pathogen: SARS-CoV-2 ...
EPFL2021A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Gerardo Turcatti, Fabien Kuttler
Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from virus ...
2020HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
Jacques Fellay, Nimisha Chaturvedi
Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This ...
NATL ACAD SCIENCES2019Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity
Harm-Anton Klok, Frederik Roman Wurm, Maarten Danial
A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...
2017Polyvalent Side Chain Peptide-Synthetic Polymer Conjugates as HIV-1 Entry Inhibitors
Harm-Anton Klok, Maarten Danial
This report describes the synthesis and properties of a series of polyvalent side chain peptide synthetic polymer conjugates designed to block the CD4 binding site on gp120 and inhibit HIV-1 entry into a host cell. The peptide sequences in the conjugates a ...
2012