Concept
Inhibiteur de fusion
Publications associées (21)
Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Philippe Colin, Aleksandar Antanasijevic
Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutralizat ...
San Francisco2023Novel broad-spectrum virucidal antivirals
The current COVID-19 pandemic has showed the threats that viruses can cause to the whole world. Over 200 million infections and over 4.5 million deaths and enormous socio-economic impact were the output of the emergence of a single new pathogen: SARS-CoV-2 ...
EPFL2021HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
Jacques Fellay, Nimisha Chaturvedi
Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This ...
NATL ACAD SCIENCES2019