Concept

Ubiquitin ligase

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Ubiquitin ligase

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Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Endoplasmic Reticulum and Lysosomal Quality Control of Four Nonsense Mutants of Iduronate 2-Sulfatase Linked to Hunter's Syndrome

Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Chemical Ligand Space of Cereblon

DNA repair protein Rad18 restricts LINE-1 mobility

Single Live Cell Monitoring of Protein Turnover Reveals Intercellular Variability and Cell-Cycle Dependence of Degradation Rates

Cytosolic delivery and characterization of monobodies interfering with SH2 domain-phosphotyrosine interactions

Dynamic protein-chromatin interactions in heterochromatin and during the DNA damage response on the single molecule level

Biochemical and biophysical characterization of ruthenation of BRCA1 RING protein by RAPTA complexes and its E3 ubiquitin ligase activity