The Paraná River (Río Paraná ˈri.o paɾaˈna; Rio Paraná ˈʁi.u paɾaˈna; Ysyry Parana) is a river in south-central South America, running through Brazil, Paraguay, and Argentina for some . Among South American rivers, it is second in length only to the Amazon River. It merges with the Paraguay River and then farther downstream with the Uruguay River to form the Río de la Plata and empties into the Atlantic Ocean.
The first European to go up the Paraná River was the Venetian explorer Sebastian Cabot, in 1526, while working for Spain.
A drought hit the river in 2021, causing a 77-year low.
In eastern South America there is "an immense number of river names containing the element para- or parana-", from Guarani language words meaning "river" or "sea"; attempts to derive a more precise meaning for the name of this, the largest of them, e.g. "kin of the sea", have been discounted.
The course is formed at the confluence of the Paranaiba and Rio Grande rivers in southern Brazil. From the confluence the river flows in a generally southwestern direction for about before encountering the city of Saltos del Guaira, Paraguay. This was once the location of the Guaíra Falls (Sete Quedas waterfalls, where the Paraná fell over a series of seven cascades. This natural feature was said to rival the world-famous Iguazu Falls to the south. The falls were flooded, however, by the construction of the Itaipu Dam, which began operating in 1984.
For approximately the next the Paraná flows southward and forms a natural boundary between Paraguay and Brazil until the confluence with the Iguazu River. Shortly upstream from this confluence, however, the river is dammed by the Itaipu Dam, the second largest hydroelectric power plant in the world (following the Three Gorges Dam in the People's Republic of China), and creating a massive, shallow reservoir behind it.
After merging with the Iguazu, the Paraná then becomes the natural border between Paraguay and Argentina. Overlooking the Paraná River from Encarnación, Paraguay, across the river, is downtown Posadas, Argentina.