Publications related to Serotonin–norepinephrine reuptake inhibitor

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Florence Pojer, Kelvin Ka Ching Lau, Oliver Hantschel, Grégory La Sala

The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere ...

2020

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

Christian Heinis, Gerardo Turcatti, Julien Bortoli Chapalay, Alessandro Angelini, Alessandro Zorzi, Jonathan Patrice Vesin, Ganesh Kumar Mothukuri, Sangram Shivdas Kale, Carl Leonard Stenbratt

Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three ...

2020

Serotonergic Modulation of Walking in Drosophila

Pavan P Ramdya, Chin-Lin Chen

To navigate complex environments, animals must generate highly robust, yet flexible, locomotor behaviors. For example, walking speed must be tailored to the needs of a particular environment. Not only must animals choose the correct speed and gait, they mu ...

CELL PRESS2019

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Stewart Cole, Anthony Vocat

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpi ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Modeling and treatment optimization of pharmaceutically active compounds by the photo-Fenton process: The case of the antidepressant Venlafaxine

César Pulgarin, Sami Rtimi, Stefanos Giannakis, Idriss Hendaoui

In this study, the anti-depressant Venlafaxine, a new emerging contaminant of interest for the Swiss legislation, was subjected to systematic degradation. In order to develop an efficient framework for the treatment of emerging contaminants at industrial s ...

Elsevier Sci Ltd2017

Solar photo-Fenton and UV/H2O2 processes against the antidepressant Venlafaxine in urban wastewaters and human urine. Intermediates formation and biodegradability assessment

Hubert Girault, César Pulgarin, Dominique Grandjean, Luiz Felippe De Alencastro, Stefanos Giannakis, Milica Jovic, Idriss Hendaoui

In this work, the use of Advanced Oxidation Processes (AOPs) against the degradation of an emerging contaminant has been subjected under systematic investigation. The optimization of treatment of the anti- depressant drug Venlafaxine (VFA) was performed, u ...

Elsevier Science Sa2017

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Horst Vogel, Henning Paul-Julius Stahlberg, Ghérici Hassaïne

The mouse serotonin 5-HT3A receptor is a homo-pentameric ligand-gated ion channel (pLGIC) mediating fast excitatory neurotransmission in the central nervous system. The molecular mechanism of ion permeation of 5-HT3A receptors triggered by the neurotransmi ...

Pergamon-Elsevier Science Ltd2017

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Pierre Magistretti, Jean-René Cardinaux

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...

Elsevier2016

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Serotonin–norepinephrine reuptake inhibitor

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

Serotonergic Modulation of Walking in Drosophila

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Modeling and treatment optimization of pharmaceutically active compounds by the photo-Fenton process: The case of the antidepressant Venlafaxine

Differentiating Siblings: The Case of Dopamine and Norepinephrine

Solar photo-Fenton and UV/H2O2 processes against the antidepressant Venlafaxine in urban wastewaters and human urine. Intermediates formation and biodegradability assessment

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Allosteric kinase inhibitors

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Graph Chatbot

Chat with Graph Search

Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Serotonergic Modulation of Walking in Drosophila

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Modeling and treatment optimization of pharmaceutically active compounds by the photo-Fenton process: The case of the antidepressant Venlafaxine

Differentiating Siblings: The Case of Dopamine and Norepinephrine

Allosteric kinase inhibitors

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Solar photo-Fenton and UV/H2O2 processes against the antidepressant Venlafaxine in urban wastewaters and human urine. Intermediates formation and biodegradability assessment