Inhibiteur de la recapture de la sérotonine et de la noradrénaline

Publications associées (27)

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Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Florence Pojer, Kelvin Ka Ching Lau, Oliver Hantschel, Tim Kükenshöner, Grégory La Sala

The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere ...

Nature Research2020

Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons

Brian Donal McCabe

Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both "classical" and "modulatory" signals that could produce diverse and/or ...

2020

Serotonergic Modulation of Walking in Drosophila

Pavan P Ramdya, Chin-Lin Chen

To navigate complex environments, animals must generate highly robust, yet flexible, locomotor behaviors. For example, walking speed must be tailored to the needs of a particular environment. Not only must animals choose the correct speed and gait, they mu ...

CELL PRESS2019

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Stewart Cole, Anthony Vocat

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpi ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Microchannel-based technologies for nerve interfacing

Sandra Gribi

Biomedical technologies in neuroprosthetics are made to restore or replace functions from the nervous system, as well as alleviate pathological conditions. Peripheral nerve interfaces use neuromodulatory techniques to inhibit pain or depression, prevent ep ...

EPFL2019

Modeling and treatment optimization of pharmaceutically active compounds by the photo-Fenton process: The case of the antidepressant Venlafaxine

César Pulgarin, Sami Rtimi, Stefanos Giannakis, Idriss Hendaoui

In this study, the anti-depressant Venlafaxine, a new emerging contaminant of interest for the Swiss legislation, was subjected to systematic degradation. In order to develop an efficient framework for the treatment of emerging contaminants at industrial s ...

Elsevier Sci Ltd2017

Solar photo-Fenton and UV/H2O2 processes against the antidepressant Venlafaxine in urban wastewaters and human urine. Intermediates formation and biodegradability assessment

Hubert Girault, César Pulgarin, Dominique Grandjean, Luiz Felippe De Alencastro, Stefanos Giannakis, Milica Jovic, Idriss Hendaoui

In this work, the use of Advanced Oxidation Processes (AOPs) against the degradation of an emerging contaminant has been subjected under systematic investigation. The optimization of treatment of the anti- depressant drug Venlafaxine (VFA) was performed, u ...

Elsevier Science Sa2017

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Horst Vogel, Henning Paul-Julius Stahlberg, Ghérici Hassaïne

The mouse serotonin 5-HT3A receptor is a homo-pentameric ligand-gated ion channel (pLGIC) mediating fast excitatory neurotransmission in the central nervous system. The molecular mechanism of ion permeation of 5-HT3A receptors triggered by the neurotransmi ...

Pergamon-Elsevier Science Ltd2017

The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Pierre Magistretti, Jean-René Cardinaux

Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better ...

Elsevier2016

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression

Pierre Magistretti, Jean-René Cardinaux

Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood di ...

Nature Publishing Group2016

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