Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, the group of viruses cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS and COVID-19. As of 2021, 45 species are registered as coronaviruses, whilst 11 diseases have been identified, as listed below.
Coronaviruses are known for their shape resembling a stellar corona, such as that of the Sun visible during a total solar eclipse; corona is derived from the Latin word corōna, meaning 'garland, wreath, crown'. It was coined by Tony Waterson (professor of virology at St Thomas' Hospital) in a meeting with his colleagues June Almeida and David Tyrrell, the founding fathers of coronavirus studies, and was first used in a Nature article in 1968, with approval by the International Committee for the Nomenclature of Viruses three years later.
The first coronavirus disease was discovered in the late 1920s, however, the most recent common ancestor of coronaviruses is estimated to have existed as recently as 8000 BCE. For a long time, coronaviradae were of limited interest to the wider scientific community, although this changed after SARS. Human coronaviruses were discovered in the 1960s, through a variety of experiments in the United States and the United Kingdom. A common origin in human coronaviruses is bats.
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Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS and COVID-19, which is causing the ongoing pandemic. In cows and pigs they cause diarrhea, while in mice they cause hepatitis and encephalomyelitis.
RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases. These include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), endo ...
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Background Immersive virtual reality (iVR)-based digital therapeutics are gaining clinical attention in the field of pain management. Based on known analogies between pain and dyspnoea, we investigated the effects of visual respiratory feedback on persiste ...
Coronaviruses represent global health threat. In this century, they have already caused two epidemics and one serious pandemic. Although, at present, there are no approved drugs and therapies for the treatment and prevention of human coronaviruses, several ...