Publications related to Automated insulin delivery system

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Sandrine Gerber, Qixing Zhang, Yi Wang, Léo Bühler

Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...

2022

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Johan Auwerx, Kristina Schoonjans

Sirtuin 3 (SIRT3) is a protein deacetylase regulating beta-cell function through inhibiting oxidative stress in obese and diabetic mice, but the detailed mechanism and potential effect of beta-cell-specific SIRT3 on metabolic homeostasis, and its potential ...

AMER DIABETES ASSOC2021

Modeling and performance investigation of insulin injection pen for diabetic persons

Catherine Dehollain, Maria-Alexandra Paun

This paper is focused on modeling and performance investigation of insulin injection pens used by diabetic persons. A smart pen cap with two electrodes is used as a capacitive sensor for insulin dose detection and is presented in details. To faithfully ana ...

IEEE2019

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Catherine Dehollain, Maria-Alexandra Paun, Jean-Baptiste Robert Orhan

A fully parameterized three-dimensional model with specific dimensions has been developed in ANSYS for an insulin injection pen used by diabetic persons. The insulin injection pen has a smart pen cap which hosts four electrodes used for the smart pen cap e ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Catherine Dehollain, Umberto De Marchi, Bakul Jitendra Vinchhi, Nicolas Bouche, Christophe Boss, Ninad Dilip Agashe

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

IEEE2019

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Sandrine Gerber, François Rémi Pierre Noverraz, Daniel Ortiz Trujillo, Luca Szabó, Léo Bühler

The controlled release of small molecular modulators of the immune response from hydrogel microspheres (MS) used for cell immobilization is an attractive approach to reduce pericapsular fibrotic overgrowth (PFO) after transplantation. Ketoprofen is a well- ...

2018

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Johan Auwerx, Dongryeol Ryu

Reduced mitochondria! electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded p ...

Rockefeller Univ Press2017

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Sandrine Gerber, Jutta Christine Wandrey, Redouan Mahou

Background: Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets. Methods: Human MSC ...

Biomed Central Ltd2017

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Jeffrey Alan Hubbell, Steinunn Baekkeskov Hanahan, Edward Allen Phelps

Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have ...

Elsevier Science Bv2017

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Automated insulin delivery system

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Modeling and performance investigation of insulin injection pen for diabetic persons

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Bioengineering strategies for inducing tolerance in autoimmune diabetes

Graph Chatbot

Chat with Graph Search

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-Cadherin interaction and prolong function of transplanted encapsulated islets in mice

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Modeling and performance investigation of insulin injection pen for diabetic persons

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Anti-fibrotic effect of ketoprofen-grafted alginate microcapsules in the transplantation of insulin producing cells

Bioengineering strategies for inducing tolerance in autoimmune diabetes