Publications related to Non-alcoholic fatty liver disease

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Kristina Schoonjans, Alessia Perino, Yasmine Sebti

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces glucago ...

Nature Publishing Group2015

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

Vassily Hatzimanikatis, Ljubisa Miskovic, Aikaterini Zisaki

Drug discovery and development is a high-risk enterprise that requires significant investments in capital, time and scientific expertise. The studies of xenobiotic metabolism remain as one of the main topics in the research and development of drugs, cosmet ...

Bentham Science Publishers2015

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Douglas Hanahan, Anguraj Sadanandam, Stephan Wullschleger, Ismaël Wafy

Seeking to assess the representative and instructive value of an engineered mouse model of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled and compared mRNA and miRNA transcriptomes of tumors from both. Mouse PanNET tumo ...

Amer Assoc Cancer Research2015

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

Johan Auwerx, Dongryeol Ryu, Eija Riitta Pirinen

No therapy for non-alcoholic steatohepatitis (NASH) has been approved so far. Roux-en-y gastric bypass (RYGB) is emerging as a therapeutic option, although its effect on NASH and related hepatic molecular pathways is unclear from human studies. We studied ...

2014

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

Johan Auwerx, Evan Graehl Williams

Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. Fos-related ...

Elsevier2014

Hepatic glucose sensing and integrative pathways in the liver

Kristina Schoonjans, Maaike Hélène Oosterveer

The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. ...

Springer Basel Ag2014

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

David Lyndon Emsley

Functional consequences of mutations in predisposition genes for familial cancer syndromes remain often elusive, especially when the corresponding gene products play pleiotropic functions and interact with numerous partners. Understanding the consequences ...

ELSEVIER SCIENCE BV2014

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

Kristina Schoonjans

Background: Liver physiology is sensitive to estrogens, which suggests that the liver might be a target of estrogenic endocrine disrupters (EED). However, the long-term consequences of neonatal exposure to EED on liver physiology have rarely been studied. ...

Informa Healthcare2014

Characterization of intracellular metabolic states in cells presenting the Warburg phenotype

Vassily Hatzimanikatis, Joana Raquel Pinto Vieira

- Cancer cells have been shown to undergo a metabolic reprogramming (Warburg effect) characterized by enhanced glycolytic fluxes and down-regulated oxidative phosphorylation even in the presence of abundant oxygen. - Experiments show that disruption of e ...

2014

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Non-alcoholic fatty liver disease

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

Hepatic glucose sensing and integrative pathways in the liver

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Characterization of intracellular metabolic states in cells presenting the Warburg phenotype

Graph Chatbot

Chat with Graph Search

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Hepatotoxicity induced by neonatal exposure to diethylstilbestrol is maintained throughout adulthood via the nuclear receptor SHP

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Characterization of intracellular metabolic states in cells presenting the Warburg phenotype

Hepatic glucose sensing and integrative pathways in the liver

Metabolic expressivity of human genetic variants: NMR metabotyping of MEN1 pathogenic mutants

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis