Publications related to Leucine

Phage display libraries of differently sized bicyclic peptides

Christian Heinis, Inmaculada Rentero Rebollo, Alessandro Angelini

Phage selections with combinatorial libraries of uniformly sized bicyclic peptides have recently yielded potent and selective binders of several protein targets. In this work we varied in a combinatorial fashion the ring sizes of bicyclic peptides in phage ...

Royal Soc Chemistry2013

Design and Synthesis of 16-Membered Cyclopeptides Active Against Vancomycin-resistant Enterococci (VRE)

Jieping Zhu

The design, synthesis and antibiotic activities of the modified carboxylate binding pocket (D-O-E ring) of vancomycin (1) were summarized in this short account. The preliminary Structure-Activity Relationship (SAR) studies indicated that both the structure ...

Schweizerische Chemische Gesellschaft2013

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

Birgit Mollwitz

The specific labeling of proteins with synthetic probes is a powerful approach to study protein function and protein tags have been widely used for this purpose. A well-established example for a self-labeling protein tag is SNAP-tag. It specifically reacts ...

EPFL2012

Neutron Reflectivity Study on the Postpolymerization Modification of Poly(2-hydroxyethyl methacrylate) Brushes

Harm-Anton Klok, Juan Pablo Hinestrosa Salazar

Postpolymerization modification reactions are widely employed to prepare functional polymer brushes. Relatively little is known, however, about the distribution of functional groups in such postmodified brushes. Using neutron reflectometry and UV-vis spect ...

American Chemical Society2011

Synthesis of Responsive Polymer Brushes for Sensing Applications

Nicolas Bertrand Schüwer

During the past decades the field of sensors has been subject to much attention due to an increased demand for (bio)sensors and environmental monitoring. The efforts have been concentrated to create sensors which are reliable, highly sensitive and selectiv ...

EPFL2011

A Post-Modification Strategy for the Synthesis of Uniform, Hydrophilic/Hydrophobic Patterned α-Hydroxy Acid Oligomers

Harm-Anton Klok, Laure Menin, Nadja Franz

Hydrophilic/hydrophobic patterning is a well-established design strategy to guide secondary structure formation of both natural as well as non-natural oligomers and polymers. This contribution explores the feasibility of a new approach for the synthesis of ...

2009

Solution behavior of peptide and peptide-hybrid materials

Harald Nuhn

Peptide based and peptide hybrid materials represent two interesting and challenging classes of biomaterials. Both classes consist of and contain, respectively, one or more polypeptide blocks, endowing the resulting polymers with enhanced self-assembly pro ...

EPFL2008

Electronic and vibrational spectroscopy of cold protonated amino acids in the gas phase

Sébastien Mercier

In this thesis report, we describe a novel home-built instrument designed to study the spectroscopy of biomolecular ions in the gas phase and at low temperature, and we present the first experimental results obtained on protonated aromatic amino acids. The ...

EPFL2008

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver

A new macrocyclic ligand,

L^3

, has been synthesised, based on the cyclen framework grafted with three phenacyl light-harvesting groups and a C5-alkyl chain bearing a carboxylic acid function as a potential linker for biological material. Acidity constant ...

2007

Ammonium Chloride Promoted Ugi Four-Component, Five-Center Reaction of alpha -Substituted alpha -Isocyano Acetic Acid: A Strong Solvent Effect

Jieping Zhu

Conditions have been developed for the multicomponent synthesis of di- and tetrapeptide based on the unique reactivity of alpha -isocyanoacetic acids (including its alpha -substituted derivs.) by an Ugi four-component, five-center reaction. Simply mixing a ...

2004

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Phage display libraries of differently sized bicyclic peptides

Design and Synthesis of 16-Membered Cyclopeptides Active Against Vancomycin-resistant Enterococci (VRE)

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

Neutron Reflectivity Study on the Postpolymerization Modification of Poly(2-hydroxyethyl methacrylate) Brushes

Synthesis of Responsive Polymer Brushes for Sensing Applications

A Post-Modification Strategy for the Synthesis of Uniform, Hydrophilic/Hydrophobic Patterned α-Hydroxy Acid Oligomers

Solution behavior of peptide and peptide-hybrid materials

Electronic and vibrational spectroscopy of cold protonated amino acids in the gas phase

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Ammonium Chloride Promoted Ugi Four-Component, Five-Center Reaction of alpha -Substituted alpha -Isocyano Acetic Acid: A Strong Solvent Effect

Structural Studies and Protein Engineering of Human O6-Alkylguanine-DNA Alkyltransferase

Non-Cytotoxic, Bifunctional EuIII and TbIII Luminescent Macrocyclic Complexes for Luminescence Resonant Energy- Transfer Experiments

Phage display libraries of differently sized bicyclic peptides

Synthesis of Responsive Polymer Brushes for Sensing Applications

Design and Synthesis of 16-Membered Cyclopeptides Active Against Vancomycin-resistant Enterococci (VRE)

Solution behavior of peptide and peptide-hybrid materials

Electronic and vibrational spectroscopy of cold protonated amino acids in the gas phase

Ammonium Chloride Promoted Ugi Four-Component, Five-Center Reaction of alpha -Substituted alpha -Isocyano Acetic Acid: A Strong Solvent Effect

A Post-Modification Strategy for the Synthesis of Uniform, Hydrophilic/Hydrophobic Patterned α-Hydroxy Acid Oligomers

Neutron Reflectivity Study on the Postpolymerization Modification of Poly(2-hydroxyethyl methacrylate) Brushes