Publications related to Olfactory receptor

Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation

Rodents depend on olfaction and touch to meet many of their fundamental needs. However, the impact of simultaneous olfactory and tactile inputs on sensory representations in the cortex remains elusive. To study these interactions, we recorded large populat ...

NATURE PORTFOLIO2022

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

Patrick Daniel Barth, Mahdi Hijazi, Aurélien Laurent Jean-Charles Oggier, Dániel Kéri

G-protein-coupled receptors (GPCRs) are the largest class of cell surface receptors and drug targets, and respond to a wide variety of chemical stimuli to activate diverse cellular functions. Understanding and predicting how ligand binding triggers a speci ...

bioRxiv2022

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Horst Vogel, Horst Pick, Thamani Dahoun, Shuguang Yuan, Marc Brugarolas Campillos

The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory receptors (ORs) to discriminate a nearly unlimited number of odorants. Cognate agonists of most ORs have not yet been identified and potential non-olfactory processes m ...

Springer2019

Microfluidic device performing on flow study of serial cell–cell interactions of two cell populations

Philippe Renaud, George Coukos, Thamani Dahoun, Margaux Catherine Marie Duchamp, Alexandre Harari, Marion Arnaud

In this study we present a novel microfluidic hydrodynamic trapping device to probe the cell–cell interaction between all cell samples of two distinct populations. We have exploited an hydrodynamic trapping method using microfluidics to immobilize a batch ...

2019

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Gerardo Turcatti, Benjamin Rappaz, Fabien Kuttler, Damiano Banfi, Pierre Marquet, Pascal Jourdain

The ionotropic GABA(A) receptors represent the main target for different groups of widely used drugs having hypnotic and anxiolytic effects. So far, most approaches used to assess GABA activity involve invasive low -throughput electrophysiological techniqu ...

2019

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

Sergey Nazarov, Petr Leiman, Sergii Buth, Nikolai Prokhorov, Michel Plattner

Bacteriophages recognize their host cells with the help of tail fiber and tailspike proteins that bind, cleave, or modify certain structures on the cell surface. The spectrum of ligands to which the tail fibers and tailspikes can bind is the primary determ ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2019

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Matteo Dal Peraro, Benoîte Bargeton

Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Mori ...

Elsevier2017

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

Johannes Broichhagen

G protein-coupled receptor (GPCR) signaling occurs in complex spatiotemporal patterns that are difficult to probe using standard pharmacological and genetic approaches. A powerful approach for dissecting GPCRs is to use light-controlled pharmacological age ...

National Academy of Sciences2017

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Olfactory receptor

Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Microfluidic device performing on flow study of serial cell–cell interactions of two cell populations

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

Boosting olfactory cocktail-party performance by semi-supervised learning in mice

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

Graph Chatbot

Chat with Graph Search

Microfluidic devices for the study of cell-cell, cell-particle and particle-particle interactions

Computational rewiring of allosteric pathways reprograms GPCR selective responses to ligands

Olfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation

Microfluidic device performing on flow study of serial cell–cell interactions of two cell populations

Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Boosting olfactory cocktail-party performance by semi-supervised learning in mice