Concept

Equilibrium unfolding

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Equilibrium unfolding

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The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins

Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins

Molecular chaperones inject energy from ATP hydrolysis into the non-equilibrium stabilisation of native proteins

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Mechanism to Trigger Unfolding in O6--Alkylguanine-DNA Alkyltransferase