Publications related to Extracellular signal-regulated kinases

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conform ...

SPRINGERNATURE2022

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Henning Paul-Julius Stahlberg, Nicolas Calo, Polina Isaikina

The human CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor (GPCR) that plays a major role in inflammation and is involved in cancer, HIV, and COVID-19. Despite its importance as a drug target, the molecular activation mechanism of CCR5, i.e., ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern

Kristin Schirmer, Jelena Petrovic

We developed phospho-ERK1/2 ELISA for human and rainbow trout liver cells, employing HepG2 and RTL-W1 cell lines as models. The assay was applied to detect changes in ERK1/2 activity for nine chemicals, added over a wide concentration range and time points ...

ELSEVIER2021

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Augusto Martins Lima, Maiia Bragina, Léa Liliane Colette Anguenot

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Laurence Gouzi Abrami, Luciano Andres Abriata, Béatrice Kunz

Capillary morphogenesis gene 2 (CMG2/ANTXR2) is a cell surface receptor for both collagen VI and anthrax toxin. Biallelic loss-of-function mutations in CMG2 lead to a severe condition, hyaline fibromatosis syndrome (HFS). We have here dissected a network o ...

CELL PRESS2020

Recent Advances and Prospects in the Research of Nascent Adhesions

Aleksandra Radenovic, Ana-Suncana Smith

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins ...

FRONTIERS MEDIA SA2020

Parallel Optical Spatial Signal Processing Based on 2x2 MIMO Computational Metasurface

Romain Christophe Rémy Fleury, Ali Momeni, Amirhossein Babaee

We introduce a novel concept of Multi-Input Multi-Output (MIMO) metasurface processor with asymmetric Optical Transfer Function (OTF) which can perform spatial first-order derivation on two orthogonal distinct input signals for both TM and TE polarizations ...

IEEE2020

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Elodie Julie Virginie Ramond, Bianca Marie Petrignani

In animals, growth is regulated by the complex interplay between paracrine and endocrine signals. When food is scarce, tissues compete for nutrients, leading to critical resource allocation and prioritization. Little is known about how the immune system ma ...

WILEY2020

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Extracellular signal-regulated kinases

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

Recent Advances and Prospects in the Research of Nascent Adhesions

Parallel Optical Spatial Signal Processing Based on 2x2 MIMO Computational Metasurface

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic beta-cells

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Regulation of Src tumor activity by its N-terminal intrinsically disordered region

Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Recent Advances and Prospects in the Research of Nascent Adhesions

The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

Parallel Optical Spatial Signal Processing Based on 2x2 MIMO Computational Metasurface

Reprogramming G Protein-Coupled Receptor Structure, Function And Signaling By Computational Design

Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic beta-cells