Concept
Familial hypercholesterolemia
Related publications (40)
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice
Jonathan Paz Montoya, Marc Moniatte
Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work sug ...
2019Hypericin can cross barriers in the chicken's chorioallantoic membrane model when delivered in low-density lipoproteins
Georges Wagnières, Veronika Huntosova
Background: Low-density lipoproteins (LDL) were used as a natural drug delivery system for the transport of hypericin (Hyp) in the bloodstream of the chicken's chorioallantoic membrane model (CAM). Hyp was chosen as a model for hydrophobic drug used in pho ...
ELSEVIER SCIENCE BV2018Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
Olivier Martin, Gerardo Turcatti, Nicolas Jean Philippe Guex, Marc Chambon
The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...
Nature Publishing Group2015Inflammatory and metabolic responses to high-fat meals with and without dairy products in men
Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of t ...
Cambridge University Press2015An Oral Formulation of Angiotensin-(1-7) Reverses Corpus Cavernosum Damages Induced by Hypercholesterolemia
Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Danielle Gomes Passos Silva
Introduction The renin angiotensin system plays a crucial role in erectile function. It has been shown that elevated angiotensin-II levels contribute to the development of erectile dysfunction (ED). Oppositely, angiotensin-(1-7) (Ang-[1-7]) mediates penile ...
Wiley-Blackwell2013Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain
Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer's disease, but the exact ...
Shenyang Editorial Dept Neural Regeneration Res2013Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes
The proprotein convertases (PCs) furin, PC5/6, and PACE4 exhibit unique and/or complementary functions. Their knockout (KO) in mice resulted in strong and specific phenotypes demonstrating that, in vivo, these PCs are unique and essential during developmen ...
American Society for Biochemistry and Molecular Biology2013