Publications related to Endothelial cell tropism

The Mammalian Membrane Microenvironment Regulates the Sequential Attachment of Bacteria to Host Cells

Alexandre Louis André Persat, Xavier Jean-Yves Pierrat

Pathogen attachment to host tissue is critical in the progress of many infections. Bacteria use adhesion in vivo to stabilize colonization and subsequently regulate the deployment of contact-dependent virulence traits. To specifically target host cells, th ...

2021

Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate

Nikolaos Stergiopoulos, Augusto Martins Lima, Tom Yohan Abraham Lachkar, Cindy Marie Elodie Khawand, Damian Salim Saint Auguste, François Cuenot

Platelets play a crucial role in the immunological response and are involved in the pathological settings of vascular diseases, and their adhesion to the extracellular matrix is important to bring leukocytes close to the endothelial cells and to form and s ...

2020

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

Michele De Palma, Mario Leonardo Squadrito, Sina Nassiri

Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent signaling cascade that facilitate ...

CELL PRESS2019

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Matthias Lütolf, Jeffrey Alan Hubbell, Yoji Tabata, Jun Ishihara, Kazuto Fukunaga

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

AMER SOC HEMATOLOGY2019

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Johan Auwerx, Tytti Heinonen

Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been ...

Nature Publishing Group2017

Resistance of echovirus 11 to ClO2 is associated with enhanced host receptor use, altered entry routes and high fitness

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Jeffrey David Jensen, Qingxia Zhong, Hyunjin Shim

Waterborne viruses can exhibit resistance to common water disinfectants, yet the mechanisms that allow them to tolerate disinfection are poorly understood. Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental evo ...

Amer Chemical Soc2017

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

Freddy Radtke, Christian Weber

A population of monocytes, known as Ly6C(lo) monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion s ...

Nature Publishing Group2016

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Elif Vardar, Kalitha Pinnagoda

Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...

Elsevier Sci Ltd2016

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Endothelial cell tropism

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

The Mammalian Membrane Microenvironment Regulates the Sequential Attachment of Bacteria to Host Cells

Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Resistance of echovirus 11 to ClO2 is associated with enhanced host receptor use, altered entry routes and high fitness

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

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Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

The Mammalian Membrane Microenvironment Regulates the Sequential Attachment of Bacteria to Host Cells

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering

Resistance of echovirus 11 to ClO2 is associated with enhanced host receptor use, altered entry routes and high fitness