Concept
Aurora kinase A
Related publications (40)
Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes
Pierre Gönczy, Alessandro De Simone
Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces ...
Amer Soc Cell Biology2017Mechanisms of centrosome separation in C. elegans
Centrosomes are the major microtubule organizing centers of animal cells. The two centrosomes present at the onset of mitosis must separate in a timely fashion along the nuclear envelope to ensure proper bipolar spindle assembly and thus genome stability. ...
EPFL2016Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation
Pierre Gönczy, Alessandro De Simone
The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms r ...
Elsevier2016Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN
Michaël Unser, Daniel Sage, Jacques Rougemont, Viesturs Simanis, Andrea Krapp, Daniel Andreas Schmitter, Anastasia Chasapi, Ioannis Xenarios
The Schizosaccharomyces pombe septation initiation network (SIN) regulates cytokinesis, and asymmetric association of SIN proteins with the mitotic spindle pole bodies (SPBs) is important for its regulation. Here, we have used semi-automated image analysis ...
Company Of Biologists Ltd2015