Concept

Aurora kinase A

Related publications (40)

Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe

The Schizosaccharomyces pombe septation initiation network (SIN) is required for cytokinesis during vegetative growth and for spore formation during meiosis. Regulation of the SIN during mitosis has been studied extensively, but less is known about its mei ...

Company of Biologists2014

Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis

Viesturs Simanis

Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast (Schizosaccharomyces pombe) is a powerful tool to study the cell cycle, bu ...

Royal Society, The2014

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans

Pierre Gönczy, Graham Knott, Simon Blanchoud, Lukas von Tobel, Tamara Mikeladze-Dvali

Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sp ...

Public Library of Science2014

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

Pierre Gönczy, Petr Strnad, Fernando Romero Balestra, Isabelle Fluckiger

Centrioles are essential for forming cilia, flagella, and centrosomes and are thus critical for a range of fundamental cellular processes. Despite their importance, the mechanisms governing centriole biogenesis remain incompletely understood. We performed ...

Cell Press2013

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

EPFL Infoscience2013

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

Pierre Gönczy, Coralie Busso, Sachin Kotak

Spindle positioning and spindle elongation are critical for proper cell division. In human cells, an evolutionary conserved ternary complex (NuMA/LGN/Gαi) anchors dynein at the cortex during metaphase, thus ensuring correct spindle positioning. Whether thi ...

Nature Publishing Group2013

Towards understanding HsSAS-6, a key player in centriole duplication

Debora Keller

The centrosome is the cell’s main microtubule organizing center. In order to assemble a proper bipolar spindle in mitosis, the cell has to duplicate its inherited single centrosome. During centrosome duplication, a single procentriole assembles approximate ...

EPFL2012

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1

Viesturs Simanis

Mitotic exit integrates the reversal of the phosphorylation events initiated by mitotic kinases with a controlled cytokinesis event that cleaves the cell in two. The mitotic exit network (MEN) of budding yeast regulates both processes, whereas the fission ...

Nature Publishing Group2012

PP2A Phosphatase Acts upon SAS-5 to Ensure Centriole Formation in C. elegans Embryos

Pierre Gönczy, Debora Keller

Centrosome duplication occurs once per cell cycle and ensures that the two resulting centrosomes assemble a bipolar mitotic spindle. Centriole formation is fundamental for centrosome duplication. In Caenorhabditis elegans, the evolutionarily conserved prot ...

Elsevier2011

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony

Aurora kinases compose a family of conserved Ser/Thr protein kinases playing essential roles in eukaryotic cell division. To date, Aurora homologues remain uncharacterized in the protozoan phylum Apicomplexa. In malaria parasites, the characterization of A ...

Wiley-Blackwell2011

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