Cotton Mather (ˈmæðər; February 12, 1663 – February 13, 1728) was a New England Puritan clergyman and writer. Educated at Harvard College, in 1685 he joined his father Increase as minister of the Congregationalist Old North Meeting House of Boston, where he continued to preach for the rest of his life.
A major intellectual and public figure in English-speaking colonial America, Cotton Mather helped lead the successful revolt of 1689 against Sir Edmund Andros, the governor imposed on New England by King James II. Mather's subsequent involvement in the Salem witch trials of 1692–1693, which he defended in the book Wonders of the Invisible World (1693), attracted intense controversy in his own day and has negatively affected his historical reputation. As a historian of colonial New England, Mather is noted for his Magnalia Christi Americana (1702).
Personally and intellectually committed to the waning social and religious orders in New England, Cotton Mather unsuccessfully sought the presidency of Harvard College, an office that had been held by his father Increase, another significant Puritan clergyman and intellectual. After 1702, Cotton Mather clashed with Joseph Dudley, the governor of the Province of Massachusetts Bay, whom Mather attempted unsuccessfully to drive out of power. Mather championed the new Yale College as an intellectual bulwark of Puritanism in New England. He corresponded extensively with European intellectuals and received an honorary Doctor of Divinity degree from the University of Glasgow in 1710.
A promoter of the new experimental science in America, Cotton Mather carried out original research on plant hybridization and on the use of inoculation as a means of preventing smallpox contagion. He dispatched many reports on scientific matters to the Royal Society of London, which elected him as a fellow in 1713. Mather's promotion of inoculation against smallpox, which he had learned about from an African named Onesimus whom Mather held as a slave, caused violent controversy in Boston during the outbreak of 1721.
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The Puritans were English Protestants in the 16th and 17th centuries who sought to rid the Church of England of Roman Catholic practices, maintaining that the Church of England had not been fully reformed and should become more Protestant. Puritanism played a significant role in English history, especially during the Protectorate. Puritans were dissatisfied with the limited extent of the English Reformation and with the Church of England's toleration of certain practices associated with the Roman Catholic Church.
Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating the body's adaptive immunity, they help prevent sickness from an infectious disease. When a sufficiently large percentage of a population has been vaccinated, herd immunity results. Herd immunity protects those who may be immunocompromised and cannot get a vaccine because even a weakened version would harm them.
Variolation was the method of inoculation first used to immunize individuals against smallpox (Variola) with material taken from a patient or a recently variolated individual, in the hope that a mild, but protective, infection would result. Only 1–2% of those variolated died from the intentional infection compared to 30% who contracted smallpox naturally. Variolation is no longer used today. It was replaced by the smallpox vaccine, a safer alternative. This in turn led to the development of the many vaccines now available against other diseases.
The role of different T cell subsets in antiviral host defense was investigated by treating thymectomized C57BL/6 and CBA/J mice with monoclonal rat anti-Lyt-2 or anti-L3/T4 IgG 2b antibodies 14 and 10 days before infection. This treatment depleted the res ...
Abstract Soil pollution with hexachlorocyclohexane (HCH) has caused serious environmental problems. Here we describe the targeted degradation of all HCH isomers by applying the aerobic bacterium Sphingobium indicum B90A. In particular, we examined possibil ...