Concept
Cytomegalovirus
Related publications (21)
Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity
Author summary Human cytomegalovirus (HCMV) infection is the foremost viral cause of congenital birth defects. Attempts to vaccinate against HCMV brought moderate, though not sufficient, reduction in infection. Moreover, phase II clinical trial with gB for ...
PUBLIC LIBRARY SCIENCE2020Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective
Kristen Kay Irwin, Jeffrey David Jensen, Susanne Petra Pfeifer, Cornelia Pokalyuk
Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this ...
Wiley2017On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations
Jeffrey David Jensen, Sebastian Matuszewski, Susanne Petra Pfeifer
Intrahost and interhost assessments of viral diversity are often treated as measures of separate and distinct evolutionary processes, with numerous investigations reporting seemingly incompatible results between the two. For example, in human cytomegalovir ...
Amer Soc Microbiology2017On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity
A central focus of population genetics has been examining the contribution of selective and neutral processes in shaping patterns of intraspecies diversity. In terms of selection specifically, surveys of higher organisms have shown considerable variation i ...
Wiley-Blackwell2016Methods for purging isolated organs and cells from latent human cytomegalovirus
The present invention relates to a method for purging ex vivo isolated organs or isolated cells from latent human cytomegalovirus (HCMV). The invention further relates to a compound for use in a method for treating HCMV infection. ...
2015Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
Didier Trono, Isabelle Barde, Adamantia Kapopoulou, Marco Cassano, Suk Min Jang, Benjamin Rauwel
Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but can be fat ...
2015Limits and patterns of cytomegalovirus genomic diversity in humans
Jeffrey David Jensen, Cornelia Pokalyuk
Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...
Natl Acad Sciences2015Human cytomegalovirus intrahost evolution - a new avenue for understanding and controlling herpesvirus infections
Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on t ...
Elsevier Sci Ltd2014Host miRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency
Reactivation of human cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients underscoring the need to understand how latency is controlled. Here we demonstrate that HCMV has evolved to utilize cellular miRNAs in ce ...
American Society for Microbiology2014Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
Populations of human cytomegalovirus (HCMV), a large DNA virus, are highly polymorphic in patient samples, which may allow for rapid evolution within human hosts. To understand HCMV evolution, longitudinally sampled genomic populations from the urine and p ...
Public Library of Science2013