Concept
Engram (neuropsychology)
Related publications (16)
Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Henry Markram, Rodrigo de Campos Perin
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...
Nature Portfolio2024Non-invasive neuromodulation of the right temporoparietal junction using theta-burst stimulation in functional neurological disorder
Background Disrupted sense of agency (SoA)-the sense of being the agent of one's own actions-has been demonstrated in patients with functional neurological disorder (FND), and a key area of the corresponding neuronal network is the right temporoparietal ju ...
London2024Tissue clearing applications in memory engram research
Johannes Gräff, Kwok Yui Reymond Yip
A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell e ...
FRONTIERS MEDIA SA2023Engram cell connectivity as a mechanism for information encoding and memory function
Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and recall. The mechanism by which those changes hold specific information is unclear. Here, we test the h ...
Cambridge2023Prefrontal engrams of long-term fear memory perpetuate pain perception
A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhan ...
NATURE PORTFOLIO2023Plasticity of sensory representations in the posterior insular cortex during fear learning
Aversively-motivated associative learning allows animals to avoid harm and thus ensures survival. Aversive learning can be studied by the fear learning paradigm, in which an innocuous sensory stimulus like a tone (conditioned stimulus, CS), acquires a nega ...
EPFL2023Lactate supply overtakes glucose when neural computational and cognitive loads scale up
Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...
NATL ACAD SCIENCES2022Epigenetic plasticity as a signature for memory allocation
Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...
EPFL2022Where does the engram come from? Study of prefrontal cortex inputs during memory consolidation
The formation and storage of memories has been under deep investigation for several decades. Nevertheless, the precise contribution of each brain region involved in this process and the interplay between them across memory consolidation is still largely de ...
EPFL2022Engram cell connectivity: an evolving substrate for information storage
Maurizio Ferdinando Pezzoli, Siddhartha Sen
Understanding memory requires an explanation for how information can be stored in the brain in a stable state. The change in the brain that accounts for a given memory is referred to as an engram. In recent years, the term engram has been operationalized a ...
CURRENT BIOLOGY LTD2021