Concept

Head and neck cancer

Related publications (228)

Photoactive sawhorse-type diruthenium tetracarbonyl complexes

Sawhorse-type diruthenium tetracarbonyl complexes incorporating carboxyphenyl porphyrin bridges and pyridine axial ligands have been prepared, characterized and evaluated as potential photosensitizing and chemotherapeutic agents in several human cancer cel ...

Elsevier2012

The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities

Michele De Palma, Douglas Hanahan

It is a time of great promise and expectation for the applications of knowledge about mechanisms of cancer toward more effective and enduring therapies for human disease. Conceptualizations such as the hallmarks of cancer are providing an organizing princi ...

2012

Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1

Michael Graetzel, Shaik Mohammed Zakeeruddin, Rosario Scopelliti, Angela Casini, Fabio Edafe, Maria Serratrice

The new gold(III) complexes: [Au{2-(2'-pyridyl) imidazolate}Cl-2] and [Au{2,6-bis(2'-benzimidazolate) pyridine}(OCOCH3)] and the mono-and binuclear gold(I) complexes: Au{2-(2'-pyridyl) imidazole} (PPh3), [Au(2-phenylimidazolate)(DAPTA)] (DAPTA = 3,7 ...

Royal Society of Chemistry2012

In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

Rolf Gruetter, Cristina Ramona Cudalbu

In the last decade, evidence has emerged indicating that the growth of a vast majority of tumors including gliomas is sustained by a subpopulation of cancer cells with stem cell properties called cancer initiating cells. These cells are able to initiate an ...

Wiley-Blackwell2012

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

Joachim Lingner

Telomerase is responsible for the immortal phenotype of cancer cells and telomerase inhibition may specifically target cancer cell proliferation. Ligands able to selectively bind to G-quadruplex telomeric DNA have been considered as telomerase inhibitors b ...

2012

Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration

Peter Martin Beard, Ivana Samarzija

Human papillomavirus (HPV) infection is considered to be a primary hit that causes cervical cancer. However, infection with this agent, although needed, is not sufficient for a cancer to develop. Additional cellular changes are required to complement the a ...

Academic Press Inc Elsevier Science2012

Identification of a Novel Wnt Inhibitor

Cancer cells are embedded in a microenvironment composed of stromal cells, such as fibroblasts, endothelial cells, infiltrating immune cells, as well as non-cellular compartments such as the extracellular matrix and secreted soluble factors. For successful ...

EPFL2012

The human CST complex is a terminator of telomerase activity

Joachim Lingner, Sophie Redon, Liuh-Yow Chen

The lengths of human telomeres, which protect chromosome ends from degradation and end fusions(1,2), are crucial determinants of cell lifespan(3). During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in c ...

Nature Publishing Group2012

Excellent Correlation between Drug Release and Portal Size in Metalla-Cage Drug-Delivery Systems

Paul Joseph Dyson, Olivier Pierre Zava

A series of large cationic hexanuclear metalla-prisms, Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(donq)(3), Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(doaq)(3) and Ru-6(p-iPrC(6)H(4)Me)(6)(tpt)(2)(dotq)(3), composed of p-cymene-ruthenium building blocks brid ...

2011

Acetal-Functionalized RAPTA Complexes for Conjugation and Labeling

Paul Joseph Dyson, Wee Han Ang

Ruthenium-arene complexes bearing the 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane ligand, namely, RAPTA compounds, are widely investigated as potential antimetastatic agents for cancer therapy. Although much evidence points toward covalent binding with ...

American Chemical Society2011

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.