Concept
Implantation (embryology)
Related publications (43)
Meeting our Makers:Uncovering the cis-regulatory activity of transposable elements using statistical learning
The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...
EPFL2024Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models
Matthias Lütolf, Stefano Davide Vianello
Research in developmental biology has been recently enriched by a multitude of in vitro models recapitulating key milestones of mammalian embryogenesis. These models obviate the challenge posed by the inaccessibility of implanted embryos, multiply experime ...
2019Soft Hydrogel Zwitterionic Coatings Minimize Fibroblast and Macrophage Adhesion on Polyimide Substrates
Silvestro Micera, Anna Zahoranova, igor lacik
Minimizing the foreign body reaction to polyimide-based implanted devices plays a pivotal role in several biomedical applications. In this work, we propose materials exhibiting nonbiofouling properties and a Young's modulus reflecting that of soft human ti ...
AMER CHEMICAL SOC2019Enhancing developmental rate and quality of mouse single blastomeres into blastocysts using a microplatform
Philippe Renaud, Leila Montazeri, Hanie Kavand
The present work reports the beneficial effects of using a microplatform on the development of mouse single blastomeres (SBs) to the blastocyst stage. Development of blastocysts from SBs separated from two‐ and four‐cell stage embryos (two‐ and four‐cell S ...
2018Robust Baseline Measurement for Reliable Fetal Heart Rate Evaluation
Cardiotocography is a measurement technique widely adopted to assess fetal well-being during both antepartum and intra-partum stages. It consists of two simultaneously acquired time-series: fetal heart rate and uterine activity. Since visual inspection ana ...
IEEE2018Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids
Denis Duboule, Matthias Lütolf, Anne-Catherine Cossy, Leonardo Beccari, Mehmet Ugur Girgin, Alfonso Martinez Arias
The emergence of multiple axes is an essential element in the establishment of the mammalian body plan. This process takes place shortly after implantation of the embryo within the uterus and relies on the activity of gene regulatory networks that coordina ...
NATURE PUBLISHING GROUP2018Lab-on-a-chip technologies for manipulation and imaging of C. elegans worms and embryos
The nematode Caenorhabditis elegans is an attractive model organism, owing notably to its short life cycle, genetic tractability, and optical transparency facilitating microscopic observation. This thesis deals with the realization of technological tools f ...
EPFL2018Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and-2 secretion by colonic epithelial cells
Kristina Schoonjans, Alessia Perino
Bile acids and epithelial-derived human beta-defensins (H beta Ds) are known to be important factors in the regulation of colonic mucosal barrier function and inflammation. We hypothesized that bile acids regulate colonic H beta D expression and aimed to t ...
Federation of American Society of Experimental Biology2017