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Aims: Inherited Retinal Disorders represent a difficult target for gene therapy. This study exploits the possibility of using CRISPR/Cas9-based gene editing in photoreceptor progenitors to prevent cell death. We performed all the experiments on Rd10 mice, ...
The recent COCO object detection dataset presents several new challenges for object detection. In particular, it contains objects at a broad range of scales, less prototypical images, and requires more precise localization. To address these challenges, we ...
Background: We present a macular dystrophy of differing severity in a single kindred caused by a heterozygous nonsense mutation in CRX. Case report: A 21 year old Caucasian male from a Swiss family was investigated for decreasing central visual acuity asso ...
In-vivo imaging of the eye's fundus is widely used to study eye's health. State of the art Adaptive Optics devices can resolve features up to a lateral resolution of 1.5 um. This resolution is still above what is needed to observe subcellular structures su ...
In crowding, target perception deteriorates in the presence of flanking elements. Crowding is classically explained by low-level mechanisms such as pooling or feature substitution. However, we have previously shown that perceptual grouping between the targ ...
Association for Research in Vision and Ophthalmology2015
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The use of 3D Magnetic Resonance Imaging (MRI) has attracted growing attention for the purpose of diagnosis and treatment planning of intraocular ocular cancers. Precise segmentation of such tumors are highly important to characterize tumors, their progres ...
We investigated Gestalt perception in the intact visual field (VF) of hemianopia patients. Three patients and matched controls performed a Yes-No figure detection task. Gabor patches of one orientation, making up the outline of a square, were embedded in r ...
PurposeTo evaluate the relationship between the peripapillary metabolic alterations [retinal vessel Oximetry (RO)] and the structural findings [retinal vessel diameter and retinal nerve fibre layer thickness (RNFL)] in patients with inherited retinal dystr ...
Currently, there is no known cure for retinitis pigmentosa (RP). Even if some treatments can slow down the progression of the disease, none of them can effectively stop retinal degeneration. This study exploits the possibility of an early intervention in p ...
Purpose:Currently, there is no known cure for Retinitis pigmentosa (RP). Even if some treatments can slow down the progression of the disease, none of them can effectively stop retinal degeneration. We exploited the possibility of an early intervention in ...