Publications related to RUNX2 | EPFL Graph Search

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

Didier Trono, Gabriela Ecco, Helen Mary Rowe

Mammalian genomes are a battleground for genetic conflict between repetitive elements and KRAB-zinc finger proteins (KZFPs). We asked whether KZFPs can regulate cell fate by using ZFP819, which targets a satellite DNA array, ZP3AR. ZP3AR coats megabase reg ...

2022

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

Johan Auwerx, Hongwei Zhu, Yuan Liu, Yan Liu, Shuai Shao

Background NCOR1 (nuclear receptor corepressor 1) is an essential coregulator of gene transcription. It has been shown that NCOR1 in macrophages plays important roles in metabolic regulation. However, the function of macrophage NCOR1 in response to myocard ...

2020

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Felix Naef, David Michael Suter, Torgil Elias Friman, Onur Tidin

The transduction of extracellular signals through signaling pathways that culminate in a transcriptional response is central to many biological processes. However, quantitative relationships between activities of signaling pathway components and transcript ...

2019

C/EBP alpha mediates the growth inhibitory effect of progestins on breast cancer cells

Cathrin Brisken, Valentina Scabia

Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide approaches to show that proges ...

WILEY2019

Nuclear Factor I genomic binding associates with chromatin boundaries

Giovanni Dietler, Giovanna Ambrosini, Jan Kerschgens, Philipp Bucher, Nicolas Mermod, Petar Pjanic, Armelle Gaussin

Background: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chromatin immuno-precipitation and high throughput sequenci ...

BioMed Central2013

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Hiroyasu Yamamoto

Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enha ...

2011

ERBIN is a new SARA-interacting protein: Competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

Georgios Sflomos

SARA, an early endosomal protein, plays a key role in TGFβ signalling, as it presents SMAD2 and SMAD3 for phosphorylation by the activated TGFβ receptors. Here, we show that ERBIN is a new SARA-interacting protein that can be recruited by SARA to early end ...

Company of Biologists2011

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation

Denis Duboule

The molecular mechanisms that govern bone and joint formation are complex, involving an integrated network of signaling pathways and gene regulators. We investigated the role of Hox genes, which are known to specify individual segments of the skeleton, in ...

American Society for Clinical Investigation2010

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RUNX2

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

C/EBP alpha mediates the growth inhibitory effect of progestins on breast cancer cells

Nuclear Factor I genomic binding associates with chromatin boundaries

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

ERBIN is a new SARA-interacting protein: Competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation

Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

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Chat with Graph Search

ERBIN is a new SARA-interacting protein: Competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Nuclear Factor I genomic binding associates with chromatin boundaries

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

C/EBP alpha mediates the growth inhibitory effect of progestins on breast cancer cells

The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation

Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice