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The transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and -delta are key regulators for the expression of the acute phase genes in the liver, such as complement component C3 and antichymotrypsin. In the brain, these acute phase proteins are ...
Many attempts to engineer cellular metab. have failed due to the complexity of cellular functions. Math. and computational methods are needed that can organize the available exptl. information, and provide insight and guidance for successful metabolic engi ...
The unidirectional steady state reaction rates of several enzymes and metabolic fluxes of distinct processes were measured simultaneously in hypoxic maize root tips using two-dimensional phosphorus NMR exchange spectroscopy. A single spectrum monitors ATP ...
The pentose phosphate pathway and the pyruvate shunt were identified as major pathways of glucose catabolism in a recombinant, riboflavin-producing Bacillus subtilis strain. Reactions connecting the tricarboxylic acid cycle and glycolysis, catalyzed by the ...
Astaxanthin is primarily used as a food supplement in the aquaculture industry, which over the past twenty years has experienced tremendous growth. A complex synthetic process produces almost all of the astaxanthin sold, and consequently, the selling price ...
Oxygen is a key substrate in animal cell metab. and its consumption is thus a parameter of great interest for bioprocess monitoring and control. A system for measuring it based on an oxygen balance on the liq. phase was developed. The use of a gas-permeabl ...
Many biological processes, from cellular metabolism to population dynamics, are characterized by allometric scaling (power-law) relationships between size and rate(1-10). An outstanding question is whether typical allometric scaling relationships-the power ...
Achieving practical biotechnol. processes for the prodn. of fine chems. requires optimization of metabolic fluxes. Attempts to alter the fluxes through a given pathway may be frustrated by compensatory changes in coupled pathways or by unexpected effects s ...
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, lep ...
Continuous cultures of a hybridoma cell line (Zac3) were performed with 2 14C-labeled substrates: glucose and glutamine. A simplified network was used to describe cell metab. This simple network gave a good idea of the main fluxes into the cell, esp. for c ...
